PMID- 12445918
OWN - NLM
STAT- MEDLINE
DCOM- 20030204
LR  - 20190916
IS  - 0303-8467 (Print)
IS  - 0303-8467 (Linking)
VI  - 105
IP  - 1
DP  - 2002 Dec
TI  - Elevated 14-3-3 protein and axonal loss in immunoglobulin-responsive, idiopathic 
      acute transverse myelitis.
PG  - 18-22
AB  - OBJECTIVES: To report the elevation of the 14-3-3 protein and the complete 
      denervation of hand muscles in idiopathic acute transverse myelitis (IATM) of the 
      cervical cord. CASE DESCRIPTION: In a 29-year-old woman with a 2-week history of 
      neck pain and repeated attenuated flus, subacute quadriplegia, hypaesthesia of 
      both arms, a T3 sensory level, and urinary dysfunction occurred. Based upon the 
      clinical findings, the cervical MRIs, and an elevated 14-3-3 protein in the CSF, 
      IATM C4-C7 was diagnosed. Ten, 17, 28 and 61 days after onset, nerve conduction 
      studies revealed complete denervation of the right abductor pollicis brevis and 
      abductor digiti minimi muscles but gradual improvement of the compound muscle 
      action potential of the left abductor pollicis brevis muscle. F-waves of the 
      right median nerve were absent. Tibial somatosensory evoked potentials showed a 
      prolonged central conduction time. Transcranial magnetic stimulation evoked a 
      response in the left but not the right abductor digiti minimi muscle. CONCLUSION: 
      IATM may cause elevation of the 14-3-3 protein and loss of motor axons 
      originating from affected anterior horn cells.
FAU - Finsterer, J
AU  - Finsterer J
AD  - Neurological Hospital, Rosenhugel, Vienna, Austria. duarte@jet2web.cc
FAU - Voigtlander, T
AU  - Voigtlander T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Netherlands
TA  - Clin Neurol Neurosurg
JT  - Clinical neurology and neurosurgery
JID - 7502039
RN  - 0 (14-3-3 Proteins)
RN  - 0 (Immunoglobulins, Intravenous)
RN  - EC 1.14.16.2 (Tyrosine 3-Monooxygenase)
SB  - IM
MH  - 14-3-3 Proteins
MH  - Adult
MH  - Atrophy/pathology
MH  - Axons/*pathology
MH  - Electromyography
MH  - Evoked Potentials, Somatosensory/physiology
MH  - Female
MH  - Humans
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Magnetic Resonance Imaging
MH  - Median Nerve/physiopathology
MH  - Muscle, Skeletal/innervation
MH  - Myelitis, Transverse/*drug therapy/*metabolism/physiopathology
MH  - Neural Conduction/physiology
MH  - Spinal Cord/pathology
MH  - Tyrosine 3-Monooxygenase/cerebrospinal fluid/*metabolism
EDAT- 2002/11/26 04:00
MHDA- 2003/02/05 04:00
CRDT- 2002/11/26 04:00
PHST- 2002/11/26 04:00 [pubmed]
PHST- 2003/02/05 04:00 [medline]
PHST- 2002/11/26 04:00 [entrez]
AID - S0303846702000860 [pii]
AID - 10.1016/s0303-8467(02)00086-0 [doi]
PST - ppublish
SO  - Clin Neurol Neurosurg. 2002 Dec;105(1):18-22. doi: 10.1016/s0303-8467(02)00086-0.