PMID- 12446956
OWN - NLM
STAT- MEDLINE
DCOM- 20030515
LR  - 20191106
IS  - 0921-8912 (Print)
IS  - 1878-3651 (Electronic)
IS  - 0921-8912 (Linking)
VI  - 24
IP  - 2-3
DP  - 2002
TI  - Genetic alterations in presumptive precursor lesions of breast carcinomas.
PG  - 69-76
AB  - The hypothetical multistep model of breast carcinogenesis suggests a transition 
      from normal epithelium to invasive carcinoma via intraductal hyperplasia (without 
      and with atypia) and in situ carcinoma. These presumptive precursor lesions are 
      currently defined by their histological features, and their prognosis is 
      imprecisely estimated from indirect epidemiological evidence. Cytogenetic and 
      molecular-genetic analysis of these lesions give evidence for an accumulation of 
      various genetic alterations during breast tumorigenesis. Using 
      immuno-histochemistry overexpression of the c-erbB-2 oncogene was found in ductal 
      carcinoma in situ (DCIS), but not in atypical intraductal hyperplasia (AIDH) and 
      intraductal hyperplasia (IDH). An expression of mutant p53 tumor suppressor gene 
      as well as expression of cyclin D1 was identified in DCIS. In IDH lesions loss of 
      heterozygosity (LOH) at various loci could be identified, and comparative genomic 
      hybridization (CGH) and fluorescence in situ hybridization (FISH) studies 
      delivered evidence for DNA amplification on chromosomal region 20q13 in the early 
      stage of IDH.However, little is currently known about genetic alterations in 
      those premalignant lesions, and the chronology of genetic alterations and 
      histopathological changes during carcinogenesis is mainly undiscovered.
FAU - Aubele, Michaela
AU  - Aubele M
AD  - GSF-National Research Center for Environment and Health, Institute of Pathology 
      Neuherberg, Germany. auble@gsf.de
FAU - Werner, Martin
AU  - Werner M
FAU - Hofler, Heinz
AU  - Hofler H
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Anal Cell Pathol
JT  - Analytical cellular pathology : the journal of the European Society for 
      Analytical Cellular Pathology
JID - 8911016
SB  - IM
MH  - Breast Neoplasms/*genetics
MH  - Cell Transformation, Neoplastic/*genetics
MH  - Female
MH  - Gene Expression Profiling/methods
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence/methods
MH  - Loss of Heterozygosity/genetics
MH  - Oncogenes/genetics/physiology
PMC - PMC4618575
EDAT- 2002/11/26 04:00
MHDA- 2003/05/16 05:00
PMCR- 2002/01/01
CRDT- 2002/11/26 04:00
PHST- 2002/11/26 04:00 [pubmed]
PHST- 2003/05/16 05:00 [medline]
PHST- 2002/11/26 04:00 [entrez]
PHST- 2002/01/01 00:00 [pmc-release]
AID - 371680 [pii]
AID - 10.1155/2002/371680 [doi]
PST - ppublish
SO  - Anal Cell Pathol. 2002;24(2-3):69-76. doi: 10.1155/2002/371680.