PMID- 12447678
OWN - NLM
STAT- MEDLINE
DCOM- 20030123
LR  - 20220419
IS  - 0945-6317 (Print)
IS  - 0945-6317 (Linking)
VI  - 441
IP  - 5
DP  - 2002 Nov
TI  - Molecular cytogenetic mapping of recurrent chromosomal breakpoints in 
      tenosynovial giant cell tumors.
PG  - 475-80
AB  - Tenosynovial giant cell tumor (TGCT) is the most common benign tumor of synovium 
      and tendon sheath. Cytogenetic data indicate that 1p11-13 is the region most 
      frequently involved in structural rearrangements. With the aim of eventually 
      identifying the genes associated with TGCT development, we have investigated 
      1p11-13 breakpoints using fluorescence in situ hybridization (FISH) analysis, 
      with a panel of yeast artificial chromosome (YAC) probes covering 1p11-21. 
      Twenty-six tumors were analyzed by G-banding, and 24 of these showed a breakpoint 
      in 1p11-13. The cytogenetic findings add to previous observations that, among a 
      variety of translocations involving 1p11-13, chromosome 2 is the most common 
      translocation partner, with a breakpoint in 2q35-37. This aberration was found in 
      eight cases. Other recurrent translocation partners, found in two or three cases, 
      were 5q22-31, 11q11-12, and 8q21-22. Material from 21 tumors was available for 
      FISH analysis, which revealed that the breakpoints clustered to one region 
      spanned by two YAC probes, 914F6 and 885F12 located in 1p13.2, in 18 cases. 
      Bacterial artificial chromosome probes were used to map the recurrent breakpoint 
      on chromosome 2. In four of seven cases there was a breakpoint within the 
      sequence covered by probe 260J21, where the RDC1 gene is located, a gene reported 
      to fuse with HMGIC in lipomas with a 2;12 translocation.
FAU - Nilsson, M
AU  - Nilsson M
AD  - Department of Clinical Genetics, University Hospital, 221 85 Lund, Sweden. 
      malin.nilsson@klingen.lu.se
FAU - Hoglund, M
AU  - Hoglund M
FAU - Panagopoulos, I
AU  - Panagopoulos I
FAU - Sciot, R
AU  - Sciot R
FAU - Dal Cin, P
AU  - Dal Cin P
FAU - Debiec-Rychter, M
AU  - Debiec-Rychter M
FAU - Mertens, F
AU  - Mertens F
FAU - Mandahl, N
AU  - Mandahl N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20020413
PL  - Germany
TA  - Virchows Arch
JT  - Virchows Archiv : an international journal of pathology
JID - 9423843
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosome Banding
MH  - Chromosome Breakage
MH  - *Chromosome Fragility
MH  - Female
MH  - Giant Cell Tumors/*genetics/pathology
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Male
MH  - Middle Aged
MH  - Physical Chromosome Mapping/*methods
MH  - Soft Tissue Neoplasms/*genetics/pathology
MH  - Synovial Membrane/*pathology
MH  - Tendons/*pathology
EDAT- 2002/11/26 04:00
MHDA- 2003/01/24 04:00
CRDT- 2002/11/26 04:00
PHST- 2001/12/14 00:00 [received]
PHST- 2002/02/12 00:00 [accepted]
PHST- 2002/11/26 04:00 [pubmed]
PHST- 2003/01/24 04:00 [medline]
PHST- 2002/11/26 04:00 [entrez]
AID - 10.1007/s00428-002-0640-y [doi]
PST - ppublish
SO  - Virchows Arch. 2002 Nov;441(5):475-80. doi: 10.1007/s00428-002-0640-y. Epub 2002 
      Apr 13.