PMID- 12447731
OWN - NLM
STAT- MEDLINE
DCOM- 20030102
LR  - 20111117
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 186
IP  - 11
DP  - 2002 Dec 1
TI  - Human leukocyte antigen class II and cervical cancer risk: a population-based 
      study.
PG  - 1565-74
AB  - The critical role of the human leukocyte antigen (HLA) system in presenting 
      peptides to antigen-specific T cell receptors may explain why only some human 
      papillomavirus (HPV)-infected women progress to cervical cancer. HLA class II 
      DRB1 and DQB1 genes were examined in 315 women with invasive squamous cell 
      cervical cancer (SCC) and 381 control subjects. Increased risks of SCC were 
      associated with DRB1*1001, DRB1*1101, and DQB1*0301, and decreased risks were 
      associated with DRB1*0301 and DRB1*13. Of squamous cell tumors, those containing 
      HPV-16 were different from those not containing HPV-16 for 3 alleles: DRB1*0401, 
      DRB1*07, and DQB1*06. Increased risks of SCC were associated with 
      DRB1*0401-DQB1*0301 (odds ratio [OR], 1.7; 95% confidence interval [CI], 1.1-2.7) 
      and DRB1*1101-DQB1*0301 (OR, 2.5; 95% CI, 1.4-4.5), and decreased risks were 
      associated with DRB1*0301-DQB1*02 (OR, 0.7; 95% CI, 0.5-1.0) and DRB1*13-DQB1*06 
      (OR, 0.6; 95% CI, 0.4-0.9) haplotypes. These results add to the evidence that 
      certain HLA class II alleles or allele combinations, or genes linked to them, 
      make some women more susceptible to SCC.
FAU - Madeleine, Margaret M
AU  - Madeleine MM
AD  - Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle 
      98109-1024, USA. mmadelei@fhcrc.org
FAU - Brumback, Babette
AU  - Brumback B
FAU - Cushing-Haugen, Kara L
AU  - Cushing-Haugen KL
FAU - Schwartz, Stephen M
AU  - Schwartz SM
FAU - Daling, Janet R
AU  - Daling JR
FAU - Smith, Anajane G
AU  - Smith AG
FAU - Nelson, J Lee
AU  - Nelson JL
FAU - Porter, Peggy
AU  - Porter P
FAU - Shera, Katherine A
AU  - Shera KA
FAU - McDougall, James K
AU  - McDougall JK
FAU - Galloway, Denise A
AU  - Galloway DA
LA  - eng
GR  - CA-42792/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20021104
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (HLA-DRB1*03:01 antigen)
RN  - 0 (HLA-DRB1*04:01 antigen)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Carcinoma, Squamous Cell/*epidemiology/genetics/virology
MH  - Case-Control Studies
MH  - Female
MH  - Genes, MHC Class II/*genetics
MH  - *Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Middle Aged
MH  - Papillomaviridae/genetics/isolation & purification
MH  - Papillomavirus Infections/complications/virology
MH  - Polymorphism, Genetic
MH  - Risk Factors
MH  - Tumor Virus Infections/complications/virology
MH  - Uterine Cervical Neoplasms/*epidemiology/genetics/virology
EDAT- 2002/11/26 04:00
MHDA- 2003/01/03 04:00
CRDT- 2002/11/26 04:00
PHST- 2002/05/22 00:00 [received]
PHST- 2002/07/29 00:00 [revised]
PHST- 2002/11/26 04:00 [pubmed]
PHST- 2003/01/03 04:00 [medline]
PHST- 2002/11/26 04:00 [entrez]
AID - JID020596 [pii]
AID - 10.1086/345285 [doi]
PST - ppublish
SO  - J Infect Dis. 2002 Dec 1;186(11):1565-74. doi: 10.1086/345285. Epub 2002 Nov 4.