PMID- 12447959
OWN - NLM
STAT- MEDLINE
DCOM- 20021231
LR  - 20131121
IS  - 0361-8609 (Print)
IS  - 0361-8609 (Linking)
VI  - 71
IP  - 4
DP  - 2002 Dec
TI  - Additional chromosomal abnormalities and variability of BCR breakpoints in 
      Philadelphia chromosome/BCR-ABL-positive acute lymphoblastic leukemia in Taiwan.
PG  - 291-9
AB  - From 1986 to 1998, 26 (23%) of 114 adult acute lymphoblastic leukemia (ALL) 
      patients and 11 (4%) of 328 pediatric patients were found to have Philadelphia 
      (Ph) chromosome. In the 30 patients with available data at diagnosis, 18 (60%) 
      had extra-chromosomal abnormalities. They included 1q duplication (5/18, 28%), 
      supernumerary Ph chromosome (4/18, 22%), 9p abnormalities (3/18, 17%), 7q 
      deletion/monosomy 7 (3/18, 17%), trisomy 19 (1/18, 6%), and trisomy 8 (1/18, 6%). 
      Excluding those with specific cytogenetic changes, only one patient had 
      hyperdiploid karyotype with more than 50 chromosomes. The incidence of 1q 
      duplication was higher and that of hyperdiploidy was lower in this study than has 
      been previously reported. There was no prognostic implication of these additional 
      cytogenetic abnormalities. With fluorescence in situ hybridization (FISH) and 
      reverse transcription-polymerase chain reaction (RT-PCR), 14 (27%) of 53 
      unselected adult ALL patients and 2 (5%) of 38 unselected pediatric patients were 
      BCR-ABL-positive, including one adult and two children without Ph chromosome. The 
      BCR-ABL fusion genes/transcripts were also present in all other 16 selected 
      Ph-positive ALL patients. The BCR-ABL fusion subtypes were determined in all 
      these 32 patients: 91% (11/12) childhood cases showed m-type fusion gene while 
      45% (9/20) adult ones did so (P = 0.0083). The clinical outcome was similar 
      between the two groups of patients with m-type and M-type BCR-ABL. In conclusion, 
      both cytogenetic and molecular studies are very helpful for identifying the 
      subgroup of ALL patients with Ph/BCR-ABL. The additional cytogenetic 
      abnormalities and subtypes of BCR-ABL fusion genes/transcripts had no significant 
      implications in this group of patients.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Ko, Bor-Sheng
AU  - Ko BS
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei, 
      Taiwan.
FAU - Tang, Jih-Lu
AU  - Tang JL
FAU - Lee, Fen-Yu
AU  - Lee FY
FAU - Liu, Ming-Chi
AU  - Liu MC
FAU - Tsai, Woei
AU  - Tsai W
FAU - Chen, Yao-Chang
AU  - Chen YC
FAU - Wang, Chiu-Hwa
AU  - Wang CH
FAU - Sheng, Ming-Chin
AU  - Sheng MC
FAU - Lin, Dong-Tsam
AU  - Lin DT
FAU - Lin, Kai-Hsin
AU  - Lin KH
FAU - Tien, Hwei-Fang
AU  - Tien HF
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Hematol
JT  - American journal of hematology
JID - 7610369
RN  - 0 (Actins)
RN  - 0 (DNA Primers)
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - Actins/genetics
MH  - Adolescent
MH  - Adult
MH  - *Chromosome Aberrations
MH  - DNA Primers
MH  - Female
MH  - Fusion Proteins, bcr-abl/*genetics
MH  - Genes, abl/*genetics
MH  - Genetic Variation/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics
MH  - Male
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/classification/genetics
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2002/11/26 04:00
MHDA- 2003/01/01 04:00
CRDT- 2002/11/26 04:00
PHST- 2002/11/26 04:00 [pubmed]
PHST- 2003/01/01 04:00 [medline]
PHST- 2002/11/26 04:00 [entrez]
AID - 10.1002/ajh.10227 [doi]
PST - ppublish
SO  - Am J Hematol. 2002 Dec;71(4):291-9. doi: 10.1002/ajh.10227.