PMID- 12452995
OWN - NLM
STAT- MEDLINE
DCOM- 20030324
LR  - 20190722
IS  - 0011-9059 (Print)
IS  - 0011-9059 (Linking)
VI  - 41
IP  - 11
DP  - 2002 Nov
TI  - HLA-DQ3 is associated with idiopathic guttate hypomelanosis, whereas HLA-DR8 is 
      not, in a group of renal transplant patients.
PG  - 744-7
AB  - BACKGROUND: The etiology of idiopathic guttate hypomelanosis (IGH) remains 
      uncertain; however, solar exposure and heredity have been proposed as causative 
      factors. OBJECTIVE: To explore the genetic predisposition to the development of 
      IGH. METHODS: A comparative case-control study was performed at a dermatology 
      department at a university hospital. Forty-seven subjects (22 renal transplant 
      patients and 25 controls) were enrolled. Clinical examination and human leukocyte 
      antigen (HLA) determination were performed. RESULTS: In the group of subjects 
      with HLA-DQ3 (10/13, P = 0.025), there was a statistically significant (P < 0.05) 
      positive association for the presence of IGH; in the group of subjects with 
      HLA-DR8 (6/6, P = 0.023), there was a statistically significant negative 
      association for the presence of IGH. CONCLUSIONS: The presence of HLA-DQ3 in 
      patients with IGH suggests a genetic basis in a group of renal transplant 
      subjects. HLA-DR8 was found in patients without IGH, and it could play a role as 
      a "protective factor" preventing subjects from developing IGH.
FAU - Arrunategui, Adriana
AU  - Arrunategui A
AD  - Department of Dermatology, School of Medicine, Universidad del Valle, Cali, 
      Colombia.
FAU - Trujillo, Rodolfo A
AU  - Trujillo RA
FAU - Marulanda, Maria P
AU  - Marulanda MP
FAU - Sandoval, Fabian
AU  - Sandoval F
FAU - Wagner, Adriana
AU  - Wagner A
FAU - Alzate, Alberto
AU  - Alzate A
FAU - Falabella, Rafael
AU  - Falabella R
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ3 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR8 antigen)
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Confidence Intervals
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - HLA-DQ Antigens/*analysis/genetics
MH  - HLA-DR Antigens/*analysis/genetics
MH  - HLA-DR Serological Subtypes
MH  - Humans
MH  - Hypopigmentation/etiology/*genetics
MH  - Kidney Transplantation
MH  - Male
MH  - Odds Ratio
MH  - Skin/pathology
EDAT- 2002/11/28 04:00
MHDA- 2003/03/26 04:00
CRDT- 2002/11/28 04:00
PHST- 2002/11/28 04:00 [pubmed]
PHST- 2003/03/26 04:00 [medline]
PHST- 2002/11/28 04:00 [entrez]
AID - 1630 [pii]
AID - 10.1046/j.1365-4362.2002.01630.x [doi]
PST - ppublish
SO  - Int J Dermatol. 2002 Nov;41(11):744-7. doi: 10.1046/j.1365-4362.2002.01630.x.