PMID- 12458052
OWN - NLM
STAT- MEDLINE
DCOM- 20021209
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 131
IP  - 1-2
DP  - 2002 Oct
TI  - Modulation of monocytes matrix metalloproteinase-2, MT1-MMP and TIMP-2 by 
      interferon-gamma and -beta: implications to multiple sclerosis.
PG  - 191-200
AB  - Recent findings have implicated the activity of matrix metalloproteinases (MMPs) 
      in the pathogenesis of multiple sclerosis (MS), while in vivo interferon 
      (IFN)-beta treatment was demonstrated to suppress MMPs. In the present study, the 
      effects mediated by IFN-gamma and IFN-beta on the mRNA and protein expression of 
      MMP-2, its physiological activator, MT1-MMP and its endogenous inhibitor, TIMP-2, 
      by monocytes were evaluated in vitro. The results point to the significance of 
      IFNs in modulating MMPs/tissue inhibitors of MMPs (TIMPs) expression, and support 
      the possibility that the therapeutic effects of IFN-beta may be, in part, due to 
      induction of a shift from "pro-" to "anti-proteolytic" pattern of MMPs and TIMPs 
      expression.
FAU - Galboiz, Yanina
AU  - Galboiz Y
AD  - Neuroimmunology Unit, Department of Neurology, Carmel Medical Center, 7 Michal 
      Street, Haifa, Israel.
FAU - Shapiro, Sarah
AU  - Shapiro S
FAU - Lahat, Nitza
AU  - Lahat N
FAU - Miller, Ariel
AU  - Miller A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (RNA, Messenger)
RN  - 127497-59-0 (Tissue Inhibitor of Metalloproteinase-2)
RN  - 77238-31-4 (Interferon-beta)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases, Membrane-Associated)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
SB  - IM
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression Regulation
MH  - Humans
MH  - Interferon-beta/*pharmacology
MH  - Interferon-gamma/*pharmacology
MH  - Matrix Metalloproteinase 2/biosynthesis/genetics
MH  - Matrix Metalloproteinases/*biosynthesis
MH  - Matrix Metalloproteinases, Membrane-Associated
MH  - Metalloendopeptidases/biosynthesis/genetics
MH  - Monocytes/drug effects/*enzymology
MH  - Multiple Sclerosis/enzymology
MH  - RNA, Messenger/biosynthesis
MH  - Tissue Inhibitor of Metalloproteinase-2/*biosynthesis/genetics
MH  - Transcription, Genetic
MH  - U937 Cells
EDAT- 2002/11/30 04:00
MHDA- 2002/12/10 04:00
CRDT- 2002/11/30 04:00
PHST- 2002/11/30 04:00 [pubmed]
PHST- 2002/12/10 04:00 [medline]
PHST- 2002/11/30 04:00 [entrez]
AID - S0165572802002667 [pii]
AID - 10.1016/s0165-5728(02)00266-7 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2002 Oct;131(1-2):191-200. doi: 10.1016/s0165-5728(02)00266-7.