PMID- 12458053
OWN - NLM
STAT- MEDLINE
DCOM- 20021209
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 131
IP  - 1-2
DP  - 2002 Oct
TI  - Antibody response to myelin oligodendrocyte glycoprotein and myelin basic protein 
      depend on familial background and are partially associated with human leukocyte 
      antigen alleles in multiplex families and sporadic multiple sclerosis.
PG  - 201-7
AB  - We investigated the association of the antibody response to myelin 
      oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP) with human 
      leukocyte antigen (HLA) class II alleles in 41 patients with sporadic multiple 
      sclerosis (MS) and 12 multiplex MS families. We found significantly increased 
      antibody response to MOG and MBP in MS patients without any difference to 
      asymptomatic relatives. HLA DRB1*04 was associated with IgM reactivity to MOG in 
      MS patients, and DRB1*15 and DRB5 with anti-MOG IgA among asymptomatic relatives. 
      We conclude that antibody responses to MOG and MBP depend on familial background. 
      Moreover, the humoral immune reactivity against MOG is partially under control of 
      certain HLA class II alleles.
FAU - Lutterotti, Andreas
AU  - Lutterotti A
AD  - Department of Neurology, University of Innsbruck, Anichstrasse 35, A-6020, 
      Innsbruck, Austria.
FAU - Reindl, Markus
AU  - Reindl M
FAU - Gassner, Christoph
AU  - Gassner C
FAU - Poustka, Katharina
AU  - Poustka K
FAU - Schanda, Kathrin
AU  - Schanda K
FAU - Deisenhammer, Florian
AU  - Deisenhammer F
FAU - Berger, Thomas
AU  - Berger T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (MOG protein, human)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (Myelin Proteins)
RN  - 0 (Myelin-Associated Glycoprotein)
RN  - 0 (Myelin-Oligodendrocyte Glycoprotein)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Autoantibodies/*blood
MH  - Family Health
MH  - Female
MH  - Gene Frequency
MH  - *Genes, MHC Class II
MH  - Genotype
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/diagnosis/*genetics/*immunology
MH  - Myelin Basic Protein/immunology
MH  - Myelin Proteins/*immunology
MH  - Myelin-Associated Glycoprotein/immunology
MH  - Myelin-Oligodendrocyte Glycoprotein
EDAT- 2002/11/30 04:00
MHDA- 2002/12/10 04:00
CRDT- 2002/11/30 04:00
PHST- 2002/11/30 04:00 [pubmed]
PHST- 2002/12/10 04:00 [medline]
PHST- 2002/11/30 04:00 [entrez]
AID - S0165572802002710 [pii]
AID - 10.1016/s0165-5728(02)00271-0 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2002 Oct;131(1-2):201-7. doi: 10.1016/s0165-5728(02)00271-0.