PMID- 12460560
OWN - NLM
STAT- MEDLINE
DCOM- 20030123
LR  - 20191106
IS  - 0969-9961 (Print)
IS  - 0969-9961 (Linking)
VI  - 11
IP  - 1
DP  - 2002 Oct
TI  - BDNF regulates the expression of fragile X mental retardation protein mRNA in the 
      hippocampus.
PG  - 221-9
AB  - Both fragile X mental retardation protein (FMRP) and brain-derived neurotrophic 
      factor (BDNF) are implicated in the maturation of neurons and in the higher 
      cognitive functions. We have investigated whether FMRP and BDNF are reciprocally 
      regulated in neurons. Exposure of cultured hippocampal neurons to BDNF, but not 
      to NT-3, reduced FMR1 mRNA levels to 84.8% of control at 4 h and the levels were 
      back to baseline by 24 h or 4 days. Furthermore, expression of FMR1 mRNA was 
      reduced (82.4% of control) in vivo in the hippocampus of transgenic mice 
      overexpressing TrkB receptors, and a small but significant (5.1%) decrease was 
      also detected in FMRP protein levels. In contrast, the expression patterns of 
      BDNF and TrkB mRNAs were not altered in FMRP-deficient mice compared to wild-type 
      mice. Our data provide evidence that BDNF via TrkB signaling decreases FMRP 
      expression and suggest a role for FMRP in BDNF-induced synaptic plasticity.
FAU - Castren, Maija
AU  - Castren M
AD  - Department of Neurobiology, A. I. Virtanen Institute, University of Kuopio, 
      FIN-70210 Kuopio, Finland.
FAU - Lampinen, Katariina E
AU  - Lampinen KE
FAU - Miettinen, Riitta
AU  - Miettinen R
FAU - Koponen, Eija
AU  - Koponen E
FAU - Sipola, Ilkka
AU  - Sipola I
FAU - Bakker, Cathy E
AU  - Bakker CE
FAU - Oostra, Ben A
AU  - Oostra BA
FAU - Castren, Eero
AU  - Castren E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fmr1 protein, mouse)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neurotrophin 3)
RN  - 0 (RNA, Messenger)
RN  - 0 (RNA-Binding Proteins)
RN  - 139135-51-6 (Fragile X Mental Retardation Protein)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Cells, Cultured
MH  - Fragile X Mental Retardation Protein
MH  - Gene Expression/drug effects
MH  - Hippocampus/cytology/*physiology
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Mice, Knockout
MH  - Nerve Tissue Proteins/*genetics
MH  - Neurotrophin 3/pharmacology
MH  - RNA, Messenger/analysis
MH  - *RNA-Binding Proteins
MH  - Receptor, trkB/physiology
EDAT- 2002/12/04 04:00
MHDA- 2003/01/24 04:00
CRDT- 2002/12/04 04:00
PHST- 2002/12/04 04:00 [pubmed]
PHST- 2003/01/24 04:00 [medline]
PHST- 2002/12/04 04:00 [entrez]
AID - S0969996102905449 [pii]
AID - 10.1006/nbdi.2002.0544 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2002 Oct;11(1):221-9. doi: 10.1006/nbdi.2002.0544.