PMID- 12460642
OWN - NLM
STAT- MEDLINE
DCOM- 20030722
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 457
IP  - 1
DP  - 2002 Dec 13
TI  - Vascular actions of 3,4-methylenedioxymethamphetamine in alpha(2A/D)-adrenoceptor 
      knockout mice.
PG  - 45-9
AB  - We have investigated the effects of 3,4-methylenedioxymethamphetamine (MDMA) on 
      mean arterial pressure in anaesthetised wild-type and alpha(2A/D)-adrenoceptor 
      knockout mice. In wild-type mice, MDMA (5 mg kg(-1)) produced a pressor response 
      that declined to baseline by 2 min and fell below baseline to a depressor 
      response by 5 min, whereas MDMA (20 mg kg(-1)) produced only a pressor response 
      that declined to baseline by 5 min. In wild-type mice, following the injection of 
      the selective alpha(2A/D)-adrenoceptor antagonist, 
      2-((4,5-dihydro-1H-imidazole-2-yl)methyl)-2,3-di-hydro-1-methyl-1H-isoindole 
      (BRL44408), the peak pressor response to MDMA (5 or 20 mg kg(-1)) was not 
      modified but durations of the pressor effects of both doses of MDMA were 
      prolonged with responses significantly above baseline at 5 min. In 
      alpha(2A/D)-adrenoceptor knockout mice, the peak response to MDMA (5 mg kg(-1)) 
      was similar to that in wild-type but the response fell to baseline over 5 min 
      with no depressor component, whereas MDMA (20 mg kg(-1)) produced a sustained 
      pressor response significantly above baseline at 10 min. The responses were 
      similar to those obtained in wild-type in the presence of BRL44408. It is 
      concluded that MDMA produces depressor responses in wild-type mice by action at 
      alpha(2A/D)-adrenoceptors to shorten the duration of the pressor response.
FAU - Vandeputte, Catherine
AU  - Vandeputte C
AD  - Department of Physiology, Royal College of Surgeons in Ireland, 123 St Stephen's 
      Green, 2, Dublin, Ireland.
FAU - Docherty, James R
AU  - Docherty JR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Adra2a protein, mouse)
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Adrenergic alpha-2 Receptor Agonists)
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Imidazoles)
RN  - 0 (Indoles)
RN  - 0 (Isoindoles)
RN  - 0 (Receptors, Adrenergic, alpha-2)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
RN  - ZET7B198W2 (BRL 44408)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/*pharmacology
MH  - Adrenergic alpha-2 Receptor Agonists
MH  - Adrenergic alpha-Antagonists/pharmacology
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Heart Rate/drug effects
MH  - Imidazoles/pharmacology
MH  - Indoles/pharmacology
MH  - Isoindoles
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Receptors, Adrenergic, alpha-2/genetics/*physiology
MH  - Time Factors
EDAT- 2002/12/04 04:00
MHDA- 2003/07/23 05:00
CRDT- 2002/12/04 04:00
PHST- 2002/12/04 04:00 [pubmed]
PHST- 2003/07/23 05:00 [medline]
PHST- 2002/12/04 04:00 [entrez]
AID - S0014299902026614 [pii]
AID - 10.1016/s0014-2999(02)02661-4 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 2002 Dec 13;457(1):45-9. doi: 10.1016/s0014-2999(02)02661-4.