PMID- 12460864
OWN - NLM
STAT- MEDLINE
DCOM- 20021220
LR  - 20220316
IS  - 1524-4539 (Electronic)
IS  - 0009-7322 (Linking)
VI  - 106
IP  - 23
DP  - 2002 Dec 3
TI  - Plasma urotensin in human systolic heart failure.
PG  - 2877-80
AB  - BACKGROUND: Human urotensin II (UTN) has potent vasoactive and cardiostimulatory 
      effects, acting on the G protein-linked receptor GPR14. Myocardial UTN expression 
      is upregulated in heart failure, and UTN stimulates myocardial expression of the 
      natriuretic peptides. We investigated plasma UTN levels in heart failure (HF; 
      left ventricular systolic dysfunction) in comparison with plasma N-terminal 
      pro-brain natriuretic peptide (N-BNP) levels. METHODS AND RESULTS: N-BNP and UTN 
      were measured in plasma from 126 patients with HF and 220 age- and sex-matched 
      controls. Both peptides were elevated in plasma of HF patients and were 
      correlated (r(s)=0.35, P<0.001). In contrast to N-BNP, there was no relationship 
      of plasma UTN with New York Heart Association (NYHA) class. Although plasma N-BNP 
      showed a positive relationship with age and female sex, there was no such 
      age-dependent change in plasma UTN, and control women had lower levels compared 
      with control men. Receiver operating characteristic curves for the diagnosis of 
      HF had areas of 0.90 and 0.86 for N-BNP and UTN, respectively (P<0.001 for both). 
      Receiver operating characteristic curve area for diagnosis of NYHA class I HF 
      with UTN was better than that with N-BNP. CONCLUSIONS: Plasma UTN is elevated in 
      HF, which suggests a pathophysiological role for this peptide. Plasma UTN may be 
      a useful alternative to N-BNP in the diagnosis of HF, inasmuch as its levels are 
      elevated irrespective of age, sex, or NYHA class.
FAU - Ng, Leong L
AU  - Ng LL
AD  - Department of Medicine and Therapeutics, University of Leicester, Leicester, UK. 
      lln1@le.ac.uk
FAU - Loke, Ian
AU  - Loke I
FAU - O'Brien, Russell J
AU  - O'Brien RJ
FAU - Squire, Iain B
AU  - Squire IB
FAU - Davies, Joan E
AU  - Davies JE
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - United States
TA  - Circulation
JT  - Circulation
JID - 0147763
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Peptide Fragments)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, G-Protein-Coupled)
RN  - 0 (UTS2R protein, human)
RN  - 0 (Urotensins)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 9047-55-6 (urotensin II)
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromatography, Gel
MH  - Female
MH  - Heart Failure/*blood/classification/*diagnosis
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain
MH  - Nerve Tissue Proteins/blood
MH  - Peptide Fragments/blood
MH  - Predictive Value of Tests
MH  - ROC Curve
MH  - Receptors, Cell Surface/metabolism
MH  - *Receptors, G-Protein-Coupled
MH  - Sex Factors
MH  - Systole
MH  - Urotensins/*blood
EDAT- 2002/12/04 04:00
MHDA- 2002/12/21 04:00
CRDT- 2002/12/04 04:00
PHST- 2002/12/04 04:00 [pubmed]
PHST- 2002/12/21 04:00 [medline]
PHST- 2002/12/04 04:00 [entrez]
AID - 10.1161/01.cir.0000044388.19119.02 [doi]
PST - ppublish
SO  - Circulation. 2002 Dec 3;106(23):2877-80. doi: 10.1161/01.cir.0000044388.19119.02.