PMID- 1246142
OWN - NLM
STAT- MEDLINE
DCOM- 19760324
LR  - 20041117
IS  - 0022-5223 (Print)
IS  - 0022-5223 (Linking)
VI  - 71
IP  - 2
DP  - 1976 Feb
TI  - Evaluation of aortic valve replacement with a porcine xenograft without long-term 
      anticoagulation.
PG  - 179-86
AB  - From June, 1971, through November, 1974, 75 patients underwent aortic valve 
      replacement with a Hancock "Stabilized Glutaraldehyde Process" porcine xenograft. 
      Patients who underwent multiple valve replacements are not included in the study. 
      Thirty-nine per cent of the patients had procedures for associated lesions or for 
      removal of a Starr-Edwards prosthesis. The operative mortality rate was 6.7 per 
      cent. Six patients died in the late postoperative period. Only one death was 
      thought to be secondary to a valve-related problem. Actuarial analysis predicts 
      84 per cent survival at 3 years. Three patients initially received long-term 
      antithromboembolic therapy. There have been three suspected or documented 
      thromboembolic episodes (0.24 per cent per patient-month). Ten per cent of the 
      patients surviving the operation developed murmurs of aortic insufficiency. There 
      have been no documented valve failures. Ninety-eight per cent of the survivors 
      have experienced an improvement in their New York Heart Association (N.Y.H.A.) 
      classification.
FAU - Pipkin, R D
AU  - Pipkin RD
FAU - Buch, W S
AU  - Buch WS
FAU - Fogarty, T J
AU  - Fogarty TJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Thorac Cardiovasc Surg
JT  - The Journal of thoracic and cardiovascular surgery
JID - 0376343
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Animals
MH  - *Anticoagulants/therapeutic use
MH  - Aortic Valve/surgery/*transplantation
MH  - Female
MH  - Follow-Up Studies
MH  - *Heart Valve Prosthesis/mortality
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Postoperative Complications/prevention & control
MH  - Swine
MH  - Thromboembolism/prevention & control
MH  - *Transplantation, Heterologous/adverse effects
EDAT- 1976/02/01 00:00
MHDA- 1976/02/01 00:01
CRDT- 1976/02/01 00:00
PHST- 1976/02/01 00:00 [pubmed]
PHST- 1976/02/01 00:01 [medline]
PHST- 1976/02/01 00:00 [entrez]
PST - ppublish
SO  - J Thorac Cardiovasc Surg. 1976 Feb;71(2):179-86.