PMID- 12463598
OWN - NLM
STAT- MEDLINE
DCOM- 20030702
LR  - 20191025
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 76
IP  - 4
DP  - 2002 Nov
TI  - Translocation t(9;22) (p23;q11) in atypical chronic myeloid leukemia (aCML) 
      presenting osteolytic lesions.
PG  - 344-8
AB  - A 58-year-old man with a 4-month history of atypical chronic myeloid leukemia 
      (aCML), treated with INF-alpha and hydroxyurea, presented with severe localized 
      bone pain with involvement of upper limbs on July 17, 2000. Cytogenetic analysis 
      of peripheral blood cells showed 46,XY,t(9;22)(p23;q11) and no BCR-ABL fusion 
      gene was detected by fluorescence in situ hybridization (FISH). On October 
      30,2000, x-rays revealed extended destruction of the bilateral proximal upper 
      limbs; pain in the femoral bones appeared in December, and the patient couldn't 
      walk. Roentgenograms taken on January 4, 2001, showed diffuse lytic changes in 
      bilateral femoral bones. On January 23, 2001, fixation of pending fractures in 
      the bilateral femoral bones with an intramedullary rod had produced good results. 
      The infiltration of immature myeloid cells was diagnosed by the histological 
      findings of a bone specimen from the right femur. Because the serum levels of 
      parathyroid hormone (PTH), PTH related protein, and calcitonin were normal, we 
      considered that the bone destruction was caused by the invasion of immature 
      myeloid cells. Four months later, the patient showed a marked increase in 
      peripheral immature granulocytes. A bone marrow specimen showed blastic marrow, 
      and he died of a brain hemorrhage. This report suggests that aCML might cause 
      destructive bone lesions prior to the disease progression. To our knowledge, this 
      is the first published case of aCML in which the chromosomal abnormality 
      t(9;22)(p23;ql 1) was detected.
FAU - Muta, Tsuyoshi
AU  - Muta T
AD  - Department of Internal Medicine, Kyushu Kosei-Nenkin Hospital, Kitakyushu City, 
      Japan. Tsuyoshi.Muta@ma8.seikyou.ne.jp
FAU - Osaki, Koichi
AU  - Osaki K
FAU - Yamano, Yujirou
AU  - Yamano Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
SB  - IM
MH  - Cerebral Hemorrhage
MH  - *Chromosomes, Human, Pair 22
MH  - *Chromosomes, Human, Pair 9
MH  - Disease Progression
MH  - Fatal Outcome
MH  - Femur/pathology
MH  - Humans
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*genetics/*pathology
MH  - Leukemic Infiltration
MH  - Male
MH  - Middle Aged
MH  - Osteolysis/*etiology
MH  - *Translocation, Genetic
EDAT- 2002/12/05 04:00
MHDA- 2003/07/03 05:00
CRDT- 2002/12/05 04:00
PHST- 2002/12/05 04:00 [pubmed]
PHST- 2003/07/03 05:00 [medline]
PHST- 2002/12/05 04:00 [entrez]
AID - 10.1007/BF02982694 [doi]
PST - ppublish
SO  - Int J Hematol. 2002 Nov;76(4):344-8. doi: 10.1007/BF02982694.