PMID- 12464552
OWN - NLM
STAT- MEDLINE
DCOM- 20030123
LR  - 20191106
IS  - 1063-4584 (Print)
IS  - 1063-4584 (Linking)
VI  - 10
IP  - 12
DP  - 2002 Dec
TI  - Long-term and resegmentation precision of quantitative cartilage MR imaging 
      (qMRI).
PG  - 922-8
AB  - OBJECTIVE: Follow up of osteoarthritis (OA) and evaluation of structure modifying 
      OA drugs require longitudinal data on cartilage structure. The aim of this study 
      was to analyse the long term and resegmentation precision of quantitative 
      cartilage analysis with magnetic resonance imaging (qMRI) in vivo, and to relate 
      precision errors to the estimated cartilage loss in OA. METHOD: Sagittal MR 
      images of the knee were obtained in 14 individuals, four datasets being acquired 
      in a first imaging session. In 12 subjects, two further datasets were acquired 
      over the next months. Image analysis was performed in the same session for image 
      data obtained under short-term and long-term imaging conditions, and in three 
      different sessions (months apart) for the first data set (resegmentation 
      precision). RESULTS: Long-term precision errors ranged from 1.4% (total knee) to 
      3.9% (total femur) for cartilage volume and thickness and were only marginally 
      higher than those under short term conditions. In the medial tibia, the error was 
      84 mm(3) compared with an estimated loss of >1,200 mm(3) in varus OA. Precision 
      errors for resegmentation were somewhat higher, but considerably smaller than the 
      intersubject variability. CONCLUSIONS: Scanner drift and changes in imaging or 
      patient conditions appear not to represent a critical problem in quantitative 
      cartilage analysis with magnetic resonance imaging (qMRI). In longitudinal 
      studies, image analysis of sequential data should be performed within the same 
      post-processing session. Under these conditions, qMRI promises to be a very 
      powerful method to assess structural change of cartilage in OA.
CI  - Copyright 2002 OsteoArthritis Research Society International. Published by 
      Elsevier Science Ltd.
FAU - Eckstein, F
AU  - Eckstein F
AD  - Musculoskeletal Research Group, Institute of Anatomy, 
      Ludwig-Maximilians-Universitat Munchen, Pettenkoferstr. 11, D-80336 Munchen, 
      Germany. eckstein@anat.med.uni-muenchen.de
FAU - Heudorfer, L
AU  - Heudorfer L
FAU - Faber, S C
AU  - Faber SC
FAU - Burgkart, R
AU  - Burgkart R
FAU - Englmeier, K-H
AU  - Englmeier KH
FAU - Reiser, M
AU  - Reiser M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
SB  - IM
MH  - Adult
MH  - Cartilage, Articular/*anatomy & histology
MH  - Female
MH  - Femur/anatomy & histology
MH  - Humans
MH  - Knee Joint/*anatomy & histology
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Tibia/anatomy & histology
EDAT- 2002/12/05 04:00
MHDA- 2003/01/24 04:00
CRDT- 2002/12/05 04:00
PHST- 2002/12/05 04:00 [pubmed]
PHST- 2003/01/24 04:00 [medline]
PHST- 2002/12/05 04:00 [entrez]
AID - S1063458402908447 [pii]
AID - 10.1053/joca.2002.0844 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2002 Dec;10(12):922-8. doi: 10.1053/joca.2002.0844.