PMID- 12465078
OWN - NLM
STAT- MEDLINE
DCOM- 20030324
LR  - 20151119
IS  - 0885-3185 (Print)
IS  - 0885-3185 (Linking)
VI  - 17
IP  - 6
DP  - 2002 Nov
TI  - Neurophysiological investigations in patients with primary writing tremor.
PG  - 1336-40
AB  - The pathophysiology of primary writing tremor (PWT) is still unknown: it has been 
      classified as a focal form of essential tremor and as a tremulous form of 
      writer's cramp. We studied cortical and spinal excitability in patients with PWT 
      and compared the results with published data of patients with essential tremor, 
      and writer's cramp. We used electrical stimulation of median and radial nerve to 
      study reciprocal inhibition of forearm antagonist muscles and paired transcranial 
      magnetic stimulation at short and long interstimulus intervals (ISIs) to assess 
      intracortical excitability. Both studies were conducted on patients with PWT and 
      on control subjects. The early (presynaptic) and late (disynaptic) phases of 
      reciprocal inhibition were normal as was intracortical excitability at short and 
      long ISIs. Our study suggests that the pathophysiology of PWT is different from 
      that of writer's cramp and partially also from that of essential tremor.
CI  - Copyright 2002 Movement Disorder Society
FAU - Modugno, Nicola
AU  - Modugno N
AD  - Dipartimento di Scienze Neurologiche, Universita di Roma La Sapienza, Roma, and 
      Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy.
FAU - Nakamura, Yusaku
AU  - Nakamura Y
FAU - Bestmann, Sven
AU  - Bestmann S
FAU - Curra, Antonio
AU  - Curra A
FAU - Berardelli, Alfredo
AU  - Berardelli A
FAU - Rothwell, John
AU  - Rothwell J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mov Disord
JT  - Movement disorders : official journal of the Movement Disorder Society
JID - 8610688
SB  - IM
MH  - Aged
MH  - Cerebral Cortex/physiopathology
MH  - Dystonic Disorders/*diagnosis/physiopathology
MH  - *Electromyography
MH  - Essential Tremor/diagnosis/physiopathology
MH  - Female
MH  - H-Reflex/physiology
MH  - *Handwriting
MH  - Humans
MH  - Magnetics
MH  - Male
MH  - Median Nerve/physiopathology
MH  - Middle Aged
MH  - Muscle, Skeletal/innervation
MH  - Neural Inhibition/physiology
MH  - Radial Nerve/physiopathology
MH  - Synaptic Transmission/physiology
MH  - Tachycardia, Paroxysmal
MH  - Tremor/*diagnosis/physiopathology
EDAT- 2002/12/05 04:00
MHDA- 2003/03/26 04:00
CRDT- 2002/12/05 04:00
PHST- 2002/12/05 04:00 [pubmed]
PHST- 2003/03/26 04:00 [medline]
PHST- 2002/12/05 04:00 [entrez]
AID - 10.1002/mds.10292 [doi]
PST - ppublish
SO  - Mov Disord. 2002 Nov;17(6):1336-40. doi: 10.1002/mds.10292.