PMID- 12468024
OWN - NLM
STAT- MEDLINE
DCOM- 20030225
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 958
IP  - 1
DP  - 2002 Dec 20
TI  - Neurons of the superior nucleus of the medial habenula and ependymal cells 
      express IL-18 in rat CNS.
PG  - 1-9
AB  - The habenular-interpeduncular pathway is involved in the modulation of several 
      functions including neuroendocrine and stress responses. Interleukin-18 (IL-18) 
      is a pro-inflammatory cytokine predominantly studied as a modulator of immune 
      functions and also produced in the adrenal cortex following activation of the 
      hypothalamic-pituitary-adrenal axis. In the central nervous system, IL-18 was 
      demonstrated to induce sleep and to influence long-term potentiation and was 
      proposed to mediate local inflammatory reactions. The present study investigated 
      the localization of IL-18 and its expression following either acute or chronic 
      restraint stress in the brain of adult male Wistar rats. Using 
      immunocytochemistry and in situ hybridization we report the unprecedented 
      localization of IL-18 in the neurons of the superior part of the medial habenula 
      (MHbS), their projections to the interpenducular nucleus and its expression in 
      the ependymal cells surrounding the third and the lateral ventricles. In 
      addition, acute (2 h) or chronic (6 h/day for 3 weeks) restraint stress induced a 
      strong elevation of IL-18 immunostaining in the MHbS but not in ependymal cells. 
      The present data suggest that IL-18 may participate in the modulation of stress 
      responses in the MHbS. They also suggest that ependymal cells may be the source 
      of IL-18 previously reported in the cerebrospinal fluid (CSF). The role of IL-18 
      in the ependyma and the CSF remains to be elucidated.
CI  - Copyright 2002 Elsevier Science B.V.
FAU - Sugama, Shuei
AU  - Sugama S
AD  - Harold L Dorris Neurological Research Center, Department of Neuropharmacology, 
      The Scripps Research Institute, 10550 North Torrey Pines Road, SR307, La Jolla, 
      CA 92037, USA.
FAU - Cho, Byung Pil
AU  - Cho BP
FAU - Baker, Harriet
AU  - Baker H
FAU - Joh, Tong H
AU  - Joh TH
FAU - Lucero, Jacinta
AU  - Lucero J
FAU - Conti, Bruno
AU  - Conti B
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Interleukin-18)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Cerebrospinal Fluid/immunology/metabolism
MH  - Efferent Pathways/cytology/immunology/*metabolism
MH  - Ependyma/cytology/immunology/*metabolism
MH  - Habenula/cytology/immunology/*metabolism
MH  - Immunohistochemistry
MH  - Interleukin-18/genetics/immunology/*metabolism
MH  - Lateral Ventricles/cytology/immunology/metabolism
MH  - Male
MH  - Neuroimmunomodulation/*physiology
MH  - Neurons/cytology/immunology/*metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Stress, Physiological/cerebrospinal fluid/*immunology/metabolism
MH  - Third Ventricle/cytology/immunology/metabolism
EDAT- 2002/12/07 04:00
MHDA- 2003/02/26 04:00
CRDT- 2002/12/07 04:00
PHST- 2002/12/07 04:00 [pubmed]
PHST- 2003/02/26 04:00 [medline]
PHST- 2002/12/07 04:00 [entrez]
AID - S0006899302033632 [pii]
AID - 10.1016/s0006-8993(02)03363-2 [doi]
PST - ppublish
SO  - Brain Res. 2002 Dec 20;958(1):1-9. doi: 10.1016/s0006-8993(02)03363-2.