PMID- 12468629
OWN - NLM
STAT- MEDLINE
DCOM- 20030122
LR  - 20181130
IS  - 0022-3166 (Print)
IS  - 0022-3166 (Linking)
VI  - 132
IP  - 12
DP  - 2002 Dec
TI  - Retinoic acid receptors and cancer.
PG  - 3809S-3813S
AB  - Retinoids have been shown to inhibit the growth of many human tumor cells. 
      Although the exact molecular mechanism of retinoid-mediated growth suppression 
      remains known, the importance of the retinoic acid receptors (RARs) and retinoid 
      X receptors (RXRs) has been in established a number of tumor cell models. We 
      wanted to determine if modulation of RAR/RXR function would alter the retinoid 
      sensitivity of oral squamous carcinoma cells (SCCs). Growth of SCCs was 
      significantly suppressed by treatment with either all-trans retinoic acid (RA) or 
      the synthetic, conformationally restricted RAR-gamma-selective retinoids SR 11254 
      and SR 11389. In contrast, stable oral SCC clones that constitutively 
      overexpressed the mouse dominant negative mutant, RAR-beta (R269Q), were shown to 
      exhibit reduced RAR/RXR transcriptional transactivation function and reduced 
      sensitivity to growth inhibition by RA, SR 11254 and SR 11389. Likewise, the 
      RAR-gamma antagonist SR 11253 was found to block the ability of SR 11254 and SR 
      11389 to inhibit SCC growth. These results indicate that modulation of RAR 
      function through the use of either an RAR-gamma-selective antagonist or a pan-RAR 
      dominant negative mutant significantly alters the growth inhibitory response of 
      oral SCCs to retinoids.
FAU - Soprano, Kenneth J
AU  - Soprano KJ
AD  - Department of Microbiology & Immunology, Temple University School of Medicine, 
      3400 North Broad Street, Philadelphia, PA 19140, USA. sopranok@astro.temple.edu
FAU - Soprano, Dianne Robert
AU  - Soprano DR
LA  - eng
GR  - CA 64945/CA/NCI NIH HHS/United States
GR  - DE 13139/DE/NIDCR NIH HHS/United States
PT  - Congress
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Nutr
JT  - The Journal of nutrition
JID - 0404243
RN  - 0 (Receptors, Retinoic Acid)
SB  - IM
MH  - Carcinoma, Squamous Cell/pathology/*physiopathology
MH  - Cell Division
MH  - Genes, Dominant
MH  - Humans
MH  - Mouth Neoplasms/pathology/*physiopathology
MH  - Receptors, Retinoic Acid/genetics/*physiology
MH  - Tumor Cells, Cultured
EDAT- 2002/12/07 04:00
MHDA- 2003/01/23 04:00
CRDT- 2002/12/07 04:00
PHST- 2002/12/07 04:00 [pubmed]
PHST- 2003/01/23 04:00 [medline]
PHST- 2002/12/07 04:00 [entrez]
AID - 10.1093/jn/132.12.3809S [doi]
PST - ppublish
SO  - J Nutr. 2002 Dec;132(12):3809S-3813S. doi: 10.1093/jn/132.12.3809S.