PMID- 12470559
OWN - NLM
STAT- MEDLINE
DCOM- 20030130
LR  - 20190916
IS  - 1472-6483 (Print)
IS  - 1472-6483 (Linking)
VI  - 4 Suppl 3
DP  - 2002
TI  - Implantation and immunology: maternal inflammatory and immune cellular responses 
      to implantation and trophoblast invasion.
PG  - 14-7
AB  - Implantation and placentation present an immune challenge because of the 
      semi-allogeneic nature of the conceptus. In this review, histological evidence 
      for maternal immune cellular responses at the implantation site is summarized. 
      Decidualization of the endometrium itself has features in common with an 
      inflammatory response. During decidualization, infiltration by uterine natural 
      killer (NK) cells occurs, and these interact with the non-polymorphic human 
      leukocyte antigen (HLA) class I antigens expressed by invading extravillous 
      trophoblasts. In humans, extension of trophoblast invasion beyond the decidual 
      layer into the myometrium presents an additional challenge, which might be 
      relevant for pregnancy complications such as pre-eclampsia. How far maternal 
      cellular responses to invading trophoblasts seen at later stages of pregnancy can 
      be traced back to the implantation period is an open question.
FAU - Pijnenborg, Robert
AU  - Pijnenborg R
AD  - Department of Obstetrics and Gynaecology, Katholieke Universiteit Leuven, B3000 
      Leuven, Belgium. Robert.Pijnenborg@uz.kuleuven.ac.be
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Reprod Biomed Online
JT  - Reproductive biomedicine online
JID - 101122473
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Embryo Implantation/*immunology
MH  - Endometrium/*immunology/physiology
MH  - Female
MH  - Histocompatibility Antigens Class I/immunology
MH  - Humans
MH  - Hypertension
MH  - Inflammation
MH  - Killer Cells, Natural/cytology/immunology
MH  - Leukocytes/immunology
MH  - Macrophages/immunology
MH  - Models, Biological
MH  - Myometrium/immunology
MH  - Neutrophils/immunology
MH  - Pregnancy
MH  - Trophoblasts/*immunology
MH  - Uterus/*immunology/physiology
RF  - 20
EDAT- 2002/12/10 04:00
MHDA- 2003/01/31 04:00
CRDT- 2002/12/10 04:00
PHST- 2002/12/10 04:00 [pubmed]
PHST- 2003/01/31 04:00 [medline]
PHST- 2002/12/10 04:00 [entrez]
AID - S1472-6483(12)60110-2 [pii]
AID - 10.1016/s1472-6483(12)60110-2 [doi]
PST - ppublish
SO  - Reprod Biomed Online. 2002;4 Suppl 3:14-7. doi: 10.1016/s1472-6483(12)60110-2.