PMID- 12470885
OWN - NLM
STAT- MEDLINE
DCOM- 20030327
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 958
IP  - 2
DP  - 2002 Dec 27
TI  - The difference of osteocalcin-immunoreactive neurons in the rat dorsal root and 
      trigeminal ganglia: co-expression with nociceptive transducers and central 
      projection.
PG  - 459-62
AB  - The co-expression of osteocalcin (OC) with the capsaicin receptor (VR1) and 
      vanilloid receptor 1-like receptor (VRL-1) was examined in the dorsal root (DRG) 
      and trigeminal ganglia (TG). Virtually all OC-immunoreactive (ir) DRG neurons 
      were devoid of VR1- and VRL-1-immunoreactivity (ir). In the TG, 14.1% of OC-ir 
      neurons were also immunoreactive for VR1. Only 1.7% of OC-ir TG neurons 
      co-expressed VRL-1-ir. The distribution of OC-ir was also examined in the spinal 
      cord and trigeminal sensory nuclei. In the spinal cord, the superficial laminae 
      of the dorsal horn were devoid of OC-ir. The neuropil was weakly stained in other 
      regions of the spinal horns. The medullary dorsal horn (MDH) contained numerous 
      OC-ir varicose fibers in laminae I and II. These fibers were occasionally 
      observed originating from the spinal trigeminal tract. The neuropil was weakly 
      stained in deeper laminae of the MDH, and the rostral parts of the trigeminal 
      sensory nuclei. The present study suggests that OC-ir TG nociceptors send their 
      unmyelinated axons to the superficial laminae of the MDH.
CI  - Copyright 2002 Elsevier Science B.V.
FAU - Ichikawa, Hiroyuki
AU  - Ichikawa H
AD  - Department of Oral Function and Anatomy, Okayama University Graduate School of 
      Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8525, Japan. 
      hiroichi@md.okayama-u.ac.jp
FAU - Sugimoto, Tomosada
AU  - Sugimoto T
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Receptors, Drug)
RN  - 104982-03-8 (Osteocalcin)
SB  - IM
MH  - Animals
MH  - Ganglia, Spinal/*chemistry/metabolism
MH  - Immunohistochemistry
MH  - Male
MH  - Neural Pathways/chemistry/immunology
MH  - Neurons/*chemistry/metabolism
MH  - Nociceptors/*chemistry/immunology
MH  - Osteocalcin/*analysis/immunology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Drug/analysis/biosynthesis
MH  - Trigeminal Ganglion/*chemistry/metabolism
EDAT- 2002/12/10 04:00
MHDA- 2003/03/28 05:00
CRDT- 2002/12/10 04:00
PHST- 2002/12/10 04:00 [pubmed]
PHST- 2003/03/28 05:00 [medline]
PHST- 2002/12/10 04:00 [entrez]
AID - S0006899302037010 [pii]
AID - 10.1016/s0006-8993(02)03701-0 [doi]
PST - ppublish
SO  - Brain Res. 2002 Dec 27;958(2):459-62. doi: 10.1016/s0006-8993(02)03701-0.