PMID- 12472275
OWN - NLM
STAT- MEDLINE
DCOM- 20021212
LR  - 20061115
IS  - 0002-9173 (Print)
IS  - 0002-9173 (Linking)
VI  - 118
IP  - 6
DP  - 2002 Dec
TI  - Value of interphase FISH for the diagnosis of t(11:14)(q13;q32) on skin lesions 
      of mantle cell lymphoma.
PG  - 832-41
AB  - The diagnosis of skin lesions of mantle cell lymphoma (MCL) may be difficult at 
      the onset of the disease. We observed 2 patients with papules of the trunk and 1 
      with diffuse infiltration of the trunk and the face and 2 subcutaneous nodules. 
      Skin samples showed diffuse infiltration of the dermis (n = 1) or perivascular 
      infiltration (n = 2). The infiltrate corresponded to centrocytic cells (n = 2) or 
      pleomorphic blastoid cells (n = 1) with a B-cell phenotype: CD3-, CD5+ (2/3), 
      CD20+, CD23-, and CD43+. In only 1 case was cyclin D1 immunoreactivity detected, 
      and the t(11;l4)(q13;q32) breakpoint was amplified from both lymph node and skin 
      DNA. Competitive reverse transcriptase-polymerase chain reaction was not 
      contributive for skin specimens. In all 3 cases, interphase fluorescence in situ 
      hybridization (FISH) demonstrated t(11;14) fusion signals either on paraffin 
      sections or on fresh frozen touch preparations of skin biopsies. The recognition 
      of skin lesions of MCL from other B-cell infiltrates can be established by 
      interphase FISH.
FAU - Dubus, Pierre
AU  - Dubus P
AD  - Histology and Molecular Pathology Laboratory, University of Bordeaux 2, France.
FAU - Young, Paul
AU  - Young P
FAU - Beylot-Barry, Marie
AU  - Beylot-Barry M
FAU - Belaud-Rotureau, Marc A
AU  - Belaud-Rotureau MA
FAU - Courville, Philippe
AU  - Courville P
FAU - Vergier, Beatrice
AU  - Vergier B
FAU - Parrens, Marie
AU  - Parrens M
FAU - Lenormand, Bernard
AU  - Lenormand B
FAU - Joly, Pascal
AU  - Joly P
FAU - Merlio, Jean P
AU  - Merlio JP
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Am J Clin Pathol
JT  - American journal of clinical pathology
JID - 0370470
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 14
MH  - Cyclin D1/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - *In Situ Hybridization, Fluorescence
MH  - Interphase
MH  - Lymphoma, Mantle-Cell/*genetics/metabolism/*pathology
MH  - Male
MH  - Middle Aged
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Skin Neoplasms/*genetics/metabolism/*pathology
MH  - *Translocation, Genetic
EDAT- 2002/12/11 04:00
MHDA- 2002/12/13 04:00
CRDT- 2002/12/11 04:00
PHST- 2002/12/11 04:00 [pubmed]
PHST- 2002/12/13 04:00 [medline]
PHST- 2002/12/11 04:00 [entrez]
AID - 10.1309/508R-YBWW-Y0AC-82GA [doi]
PST - ppublish
SO  - Am J Clin Pathol. 2002 Dec;118(6):832-41. doi: 10.1309/508R-YBWW-Y0AC-82GA.