PMID- 12472673
OWN - NLM
STAT- MEDLINE
DCOM- 20030110
LR  - 20190818
IS  - 0300-9475 (Print)
IS  - 0300-9475 (Linking)
VI  - 56
IP  - 6
DP  - 2002 Dec
TI  - IL-18 production in human pulmonary and pleural tuberculosis.
PG  - 611-8
AB  - Interleukin-18 (IL-18) has multiple important pro-inflammatory effects, including 
      the induction of interferon-gamma (IFN-gamma) in various diseases. In this study, 
      we investigated the IL-18-producing activities in human pulmonary and pleural 
      tuberculosis (TB) in response to purified protein derivative (PPD) antigen (Ag) 
      from Mycobacterium tuberculosis. The most significant IL-18 production was found 
      in chronic refractory TB (CRTB) patients. However, IFN-gamma production in CRTB 
      patients was significantly less than that in healthy tuberculin reactors or in 
      patients with tuberculous pleurisy (TBP). Elevated levels of both IL-18 and 
      IFN-gamma were found in pleural fluids from TBP patients. In vitro production of 
      IL-18 was dramatically decreased following an 18 h stimulation with PPD. However, 
      IFN-gamma was markedly increased in pleural mononuclear cells from TBP patients 
      after in vitro stimulation with PPD. The mesothelial cell type was the main 
      source of pro-IL-18 in pleural cells from TBP patients, suggesting an important 
      role for these cells in TBP. Taken together, these data indicate that IL-18 is 
      elevated in peripheral blood mononuclear cells from CRTB patients, as well as at 
      the site of TBP, indicating a possible role for IL-18 in both protective immunity 
      and pathologic responses in human TB.
FAU - Song, C-H
AU  - Song CH
AD  - Department of Microbiology, College of Medicine, Chungnam National University, 
      Taejon, Korea.
FAU - Lee, J-S
AU  - Lee JS
FAU - Nam, H-H
AU  - Nam HH
FAU - Kim, J-M
AU  - Kim JM
FAU - Suhr, J-W
AU  - Suhr JW
FAU - Jung, S-S
AU  - Jung SS
FAU - Na, M-J
AU  - Na MJ
FAU - Paik, T-H
AU  - Paik TH
FAU - Kim, H-J
AU  - Kim HJ
FAU - Park, J-K
AU  - Park JK
FAU - Jo, E-K
AU  - Jo EK
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Interleukin-18)
RN  - 0 (Protein Precursors)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tuberculin)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Cells, Cultured
MH  - Epithelium/immunology
MH  - Humans
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-18/*biosynthesis/genetics
MH  - Leukocytes, Mononuclear/immunology
MH  - Pleural Effusion/immunology
MH  - Pleurisy/immunology
MH  - Protein Precursors/biosynthesis/genetics
MH  - RNA, Messenger/biosynthesis
MH  - Tuberculin/immunology
MH  - Tuberculosis, Pleural/*immunology/pathology
MH  - Tuberculosis, Pulmonary/*immunology
MH  - Up-Regulation
EDAT- 2002/12/11 04:00
MHDA- 2003/01/11 04:00
CRDT- 2002/12/11 04:00
PHST- 2002/12/11 04:00 [pubmed]
PHST- 2003/01/11 04:00 [medline]
PHST- 2002/12/11 04:00 [entrez]
AID - 1143 [pii]
AID - 10.1046/j.1365-3083.2002.01143.x [doi]
PST - ppublish
SO  - Scand J Immunol. 2002 Dec;56(6):611-8. doi: 10.1046/j.1365-3083.2002.01143.x.