PMID- 12473084 OWN - NLM STAT- MEDLINE DCOM- 20030325 LR - 20191210 IS - 0953-816X (Print) IS - 0953-816X (Linking) VI - 16 IP - 11 DP - 2002 Dec TI - Increased BDNF and trk-B mRNA expression in cortical and limbic regions following formation of a social recognition memory. PG - 2166-74 AB - Brain-derived neurotrophic factor (BDNF) and its receptor, tyrosine receptor kinase (trk-B), play important roles in neural plasticity, long-term potentiation and memory formation. Sheep form a selective recognition memory for their lambs within 2 h of birth. Initially, this memory is exclusively based on olfactory cues; however, as it consolidates over a 12-h recognition period it extends to incorporate visual cues. We investigated whether changes in BDNF and trk-B mRNA expression occurred in both olfactory and visual processing systems at 4.5 h postpartum, 2-3 h after the behavioural manifestations of an olfactory recognition memory were found. Animals that formed a recognition memory showed increased BDNF mRNA expression in the inferior part of the temporal cortex, subfield CA1 of the hippocampus, the diagonal band, basolateral amygdala and the anterior cingulate, medial frontal, entorhinal and pyriform cortices. No increases were observed in either the olfactory bulbs or the dentate gyrus. Expression of trk-B mRNA was significantly increased only in the medial temporal, entorhinal and pyriform cortices. These findings demonstrate that by 2-3 h following the initial formation of olfactory recognition memory there are BDNF/trk-B-mediated plasticity changes in brain areas involved in the consolidation of olfactory memory (the pyriform and entorhinal cortices). However, similar changes also occur in areas of the brain involved in visual memory, face and object recognition (the temporal cortex, entorhinal cortex, hippocampal subfield CA1 and basolateral amygdala), and in areas of the brain with integrative and attentional functions (the medial frontal and anterior cingulate cortices and diagonal band). This suggests that reorganization of neural circuits underlying the visual recognition of lambs or the integration of olfactory/visual information is occurring even at this time even though accurate behavioural recognition at this stage can only be made using olfactory cues. FAU - Broad, Kevin D AU - Broad KD AD - Laboratory of Cognitive and Developmental Neuroscience, The Babraham Institute, Babraham, Cambridge CB2 4AT, UK. kevin.broad@bbsrc.ac.uk FAU - Mimmack, Mike L AU - Mimmack ML FAU - Keverne, E Barry AU - Keverne EB FAU - Kendrick, Keith M AU - Kendrick KM LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - France TA - Eur J Neurosci JT - The European journal of neuroscience JID - 8918110 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (RNA, Messenger) RN - EC 2.7.10.1 (Receptor, trkB) SB - IM MH - Animals MH - Brain/cytology/metabolism MH - Brain-Derived Neurotrophic Factor/*genetics MH - Cerebral Cortex/cytology/*metabolism MH - Cues MH - Female MH - Gene Expression Regulation/physiology MH - Limbic System/cytology/*metabolism MH - Maternal Behavior/*physiology MH - Neuronal Plasticity/genetics MH - Neurons/cytology/metabolism MH - Olfactory Pathways/cytology/metabolism MH - Pattern Recognition, Visual/physiology MH - RNA, Messenger/metabolism MH - Receptor, trkB/*genetics MH - Recognition, Psychology/*physiology MH - Sheep MH - Smell/genetics MH - Visual Pathways/cytology/metabolism EDAT- 2002/12/11 04:00 MHDA- 2003/03/26 05:00 CRDT- 2002/12/11 04:00 PHST- 2002/12/11 04:00 [pubmed] PHST- 2003/03/26 05:00 [medline] PHST- 2002/12/11 04:00 [entrez] AID - 2311 [pii] AID - 10.1046/j.1460-9568.2002.02311.x [doi] PST - ppublish SO - Eur J Neurosci. 2002 Dec;16(11):2166-74. doi: 10.1046/j.1460-9568.2002.02311.x.