PMID- 12474064
OWN - NLM
STAT- MEDLINE
DCOM- 20030801
LR  - 20101118
IS  - 0009-5915 (Print)
IS  - 0009-5915 (Linking)
VI  - 111
IP  - 5
DP  - 2002 Dec
TI  - Analysis of chromosome conservation in Lemur catta studied by chromosome paints 
      and BAC/PAC probes.
PG  - 348-56
AB  - A panel of human chromosome painting probes and bacterial and P1 artificial 
      chromosome (BAC/PAC) clones were used in fluorescence in situ hybridization 
      (FISH) experiments to investigate the chromosome conservation of the ring-tailed 
      lemur (Lemur catta, LCA) with respect to human. Whole chromosome paints specific 
      for human chromosomes 7, 9, 11, 13, 14, 17, 18, 20, 21, and X were found to 
      identify a single chromosome or an uninterrupted chromosomal region in LCA. A 
      large set of partial chromosome paints and BAC/PAC probes were then used to 
      refine the characterization of the rearrangements differentiating the two 
      karyotypes. The results were also used to reconstruct the ancestral Lemuridae 
      karyotype. Lemur catta, indeed, can be used as an outgroup, allowing 
      symplesiomorphic (ancestral) rearrangements to be distinguished from apomorphic 
      (derived) rearrangements in lemurs. Some LCA chromosomes are difficult to 
      distinguish morphologically. The 'anchorage' of most LCA chromosomes to specific 
      probes will contribute to the standardization of the karyotype of this species.
FAU - Cardone, Maria Francesca
AU  - Cardone MF
AD  - Sezione di Genetica, DAPEG, Via Amendola 165/A, 70126 Bari, Italy.
FAU - Ventura, Mario
AU  - Ventura M
FAU - Tempesta, Sergio
AU  - Tempesta S
FAU - Rocchi, Mariano
AU  - Rocchi M
FAU - Archidiacono, Nicoletta
AU  - Archidiacono N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20021009
PL  - Austria
TA  - Chromosoma
JT  - Chromosoma
JID - 2985138R
RN  - 0 (Nucleic Acid Probes)
SB  - IM
MH  - Animals
MH  - Biological Evolution
MH  - Chromosome Painting
MH  - Chromosomes/*genetics
MH  - Chromosomes, Artificial, Bacterial
MH  - Chromosomes, Artificial, P1 Bacteriophage
MH  - Karyotyping
MH  - Lemur/*genetics
MH  - Nucleic Acid Probes
MH  - Synteny/*genetics
EDAT- 2002/12/11 04:00
MHDA- 2003/08/02 05:00
CRDT- 2002/12/11 04:00
PHST- 2002/03/19 00:00 [received]
PHST- 2002/08/07 00:00 [revised]
PHST- 2002/08/22 00:00 [accepted]
PHST- 2002/12/11 04:00 [pubmed]
PHST- 2003/08/02 05:00 [medline]
PHST- 2002/12/11 04:00 [entrez]
AID - 10.1007/s00412-002-0215-3 [doi]
PST - ppublish
SO  - Chromosoma. 2002 Dec;111(5):348-56. doi: 10.1007/s00412-002-0215-3. Epub 2002 Oct 
      9.