PMID- 12475004
OWN - NLM
STAT- MEDLINE
DCOM- 20030512
LR  - 20220408
IS  - 0961-2033 (Print)
IS  - 0961-2033 (Linking)
VI  - 11
IP  - 11
DP  - 2002
TI  - Behavioral and cognitive deficits occur only after prolonged exposure of mice to 
      antiphospholipid antibodies.
PG  - 736-43
AB  - The antiphospholipid (Hughes) syndrome (APS) includes systemic and central 
      nervous system (CNS) pathology associated with antibodies to a complex of 
      phospholipids and beta2-glycoprotein I (beta2-GPI). Beta2-GPI immunized mice 
      develop systemic manifestations of APS and we presently examined CNS 
      manifestations in this APS model. Female BALB/c mice were immunized once with 
      beta2-GPI in complete Freund's adjuvant (CFA) or with CFA alone (controls). A 
      staircase test and a T-maze alternation test were performed to test behavior and 
      cognition in independent groups of mice 6, 12 and 18 weeks following the 
      immunization. The APS mice developed elevated levels of antibodies against 
      negatively charged phospholipids and beta2-GPI. Neurological impairment was 
      detected only 18 weeks after the induction of the APS and consisted of both 
      cognitive (53 +/- 4 vs 71 +/- 3% correct choices in the T-maze alternation for 
      APS vs control mice, P < 0.001) and behavioral changes (higher number of rears 
      (18 +/- 2 vs 11 +/- 1, P < 0.006) and higher number of stairs climbed (12 +/- 2 
      vs 7 +/- 1, P < 0.02). This is the first report of cognitive deficits in this APS 
      model and demonstrates the time course for the development of previously 
      described behavioral changes. The mechanism involved in these CNS manifestations 
      remains to be elucidated.
FAU - Shrot, S
AU  - Shrot S
AD  - Department of Physiology and Pharmacology, Sackler Faculty of Medicine, Tel Aviv 
      University, Israel.
FAU - Katzav, A
AU  - Katzav A
FAU - Korczyn, A D
AU  - Korczyn AD
FAU - Litvinju, Y
AU  - Litvinju Y
FAU - Hershenson, R
AU  - Hershenson R
FAU - Pick, C G
AU  - Pick CG
FAU - Blank, M
AU  - Blank M
FAU - Zaech, J
AU  - Zaech J
FAU - Shoenfeld, Y
AU  - Shoenfeld Y
FAU - Sirota, P
AU  - Sirota P
FAU - Chapman, J
AU  - Chapman J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Lupus
JT  - Lupus
JID - 9204265
RN  - 0 (Antibodies, Antiphospholipid)
RN  - 0 (Glycoproteins)
RN  - 0 (beta 2-Glycoprotein I)
SB  - IM
MH  - Animals
MH  - Antibodies, Antiphospholipid/*blood
MH  - Antiphospholipid Syndrome/complications/*immunology
MH  - Behavior, Animal
MH  - Cognition Disorders/etiology/*immunology
MH  - Female
MH  - Glycoproteins/immunology/pharmacology
MH  - Immunization
MH  - Maze Learning
MH  - Memory
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Time Factors
MH  - beta 2-Glycoprotein I
EDAT- 2002/12/12 04:00
MHDA- 2003/05/13 05:00
CRDT- 2002/12/12 04:00
PHST- 2002/12/12 04:00 [pubmed]
PHST- 2003/05/13 05:00 [medline]
PHST- 2002/12/12 04:00 [entrez]
AID - 10.1191/0961203302lu255oa [doi]
PST - ppublish
SO  - Lupus. 2002;11(11):736-43. doi: 10.1191/0961203302lu255oa.