PMID- 12476082
OWN - NLM
STAT- MEDLINE
DCOM- 20030321
LR  - 20191106
IS  - 1070-5287 (Print)
IS  - 1070-5287 (Linking)
VI  - 9
IP  - 1
DP  - 2003 Jan
TI  - The other cells in asthma: dendritic cell and epithelial cell crosstalk.
PG  - 34-41
AB  - Dendritic cells (DCs) and epithelial cells are the first cells to encounter 
      inhaled allergens. The response of these cell types to allergens is fundamentally 
      different in asthmatics compared with nonasthmatics. DCs and epithelial cells 
      interact through cell-cell interactions and through release of soluble mediators. 
      The response of epithelial cells to allergens can profoundly modify the behavior 
      of intramucosal DCs. Upon migration to the draining nodes, mucosal DCs undergo 
      functional maturation and induce proliferation in naive T cells and primed Th2 
      cells. The implications of the DC-epithelial interaction for the pathogenesis of 
      asthma is becoming increasingly clear by the use of mouse models and culture 
      systems of human cells.
FAU - Lambrecht, Bart N
AU  - Lambrecht BN
AD  - Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, the 
      Netherlands. lambrecht@lond.azr.nl
FAU - Hammad, Hamida
AU  - Hammad H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Curr Opin Pulm Med
JT  - Current opinion in pulmonary medicine
JID - 9503765
SB  - IM
MH  - Animals
MH  - Asthma/*immunology/*physiopathology
MH  - Bronchial Hyperreactivity/*immunology
MH  - Bronchoalveolar Lavage Fluid/cytology
MH  - Cross Reactions/immunology
MH  - Dendritic Cells/*immunology/physiology
MH  - Epithelial Cells/*immunology/physiology
MH  - Mice
MH  - Rats
MH  - Sensitivity and Specificity
MH  - Severity of Illness Index
MH  - Th2 Cells/immunology/physiology
RF  - 84
EDAT- 2002/12/12 04:00
MHDA- 2003/03/22 04:00
CRDT- 2002/12/12 04:00
PHST- 2002/12/12 04:00 [pubmed]
PHST- 2003/03/22 04:00 [medline]
PHST- 2002/12/12 04:00 [entrez]
AID - 10.1097/00063198-200301000-00006 [doi]
PST - ppublish
SO  - Curr Opin Pulm Med. 2003 Jan;9(1):34-41. doi: 10.1097/00063198-200301000-00006.