PMID- 12476354
OWN - NLM
STAT- MEDLINE
DCOM- 20030303
LR  - 20220321
IS  - 1355-0284 (Print)
IS  - 1538-2443 (Electronic)
IS  - 1355-0284 (Linking)
VI  - 8
IP  - 6
DP  - 2002 Dec
TI  - Tumor necrosis factor-alpha in normal and diseased brain: Conflicting effects via 
      intraneuronal receptor crosstalk?
PG  - 611-24
AB  - Tumor necrosis factor-alpha (TNF-alpha) is pleiotropic mediator of a diverse 
      array of physiological and neurological functions, including both normal 
      regulatory functions and immune responses to infectious agents. Its role in the 
      nervous system is prominent but paradoxical. Studies on uninflamed or "normal" 
      brain have generally attributed TNF-alpha a neuromodulatory effect. In contrast, 
      in inflamed or diseased brain, the abundance of evidence suggests that TNF-alpha 
      has an overall neurotoxic effect, which may be particularly pronounced for 
      virally mediated neurological disease. Still others have found TNF-alpha to be 
      protective under some conditions of neurological insult. It is still uncertain 
      exactly how TNF-alpha is able to induce these opposing effects through receptor 
      activation of only a limited set of cell signaling pathways. In this paper, we 
      provide support from the literature to advance our hypothesis that one mechanism 
      by which TNF-alpha can exert its paradoxical effects in the brain is via 
      crosstalk with signaling pathways of growth factors or other cytokines.
FAU - Perry, Seth W
AU  - Perry SW
AD  - Center for Aging and Developmental Biology, Aab Biomedical Institute, and the 
      Departments of Neurology, University of Rochester Medical Center, Rochester, New 
      York, USA. Seth_Perry@urmc.rochester.edu
FAU - Dewhurst, Stephen
AU  - Dewhurst S
FAU - Bellizzi, Matthew J
AU  - Bellizzi MJ
FAU - Gelbard, Harris A
AU  - Gelbard HA
LA  - eng
GR  - T32 AI49815/AI/NIAID NIH HHS/United States
GR  - T32 GM07356/GM/NIGMS NIH HHS/United States
GR  - T32 AI049815/AI/NIAID NIH HHS/United States
GR  - T32 GM007356/GM/NIGMS NIH HHS/United States
GR  - P01 MH64570/MH/NIMH NIH HHS/United States
GR  - P01 MH064570/MH/NIMH NIH HHS/United States
GR  - R01 MH056838/MH/NIMH NIH HHS/United States
GR  - R01 MH56838/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Neurovirol
JT  - Journal of neurovirology
JID - 9508123
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Brain/cytology/*immunology
MH  - Brain Diseases/*immunology
MH  - Humans
MH  - Neurons/immunology
MH  - Receptor Cross-Talk/*immunology
MH  - Tumor Necrosis Factor-alpha/*immunology
PMC - PMC7094979
EDAT- 2002/12/12 04:00
MHDA- 2003/03/04 04:00
PMCR- 2020/03/25
CRDT- 2002/12/12 04:00
PHST- 2002/12/12 04:00 [pubmed]
PHST- 2003/03/04 04:00 [medline]
PHST- 2002/12/12 04:00 [entrez]
PHST- 2020/03/25 00:00 [pmc-release]
AID - PAEK73867JD0VCH0 [pii]
AID - 80600611 [pii]
AID - 10.1080/13550280290101021 [doi]
PST - ppublish
SO  - J Neurovirol. 2002 Dec;8(6):611-24. doi: 10.1080/13550280290101021.