PMID- 12476543
OWN - NLM
STAT- MEDLINE
DCOM- 20030312
LR  - 20161020
IS  - 1088-5412 (Print)
IS  - 1088-5412 (Linking)
VI  - 23
IP  - 5
DP  - 2002 Sep-Oct
TI  - Interleukin-6 and mast cells.
PG  - 331-5
AB  - Interleukin (IL) 6 is a pleiotropic cytokine (26 kDa) that originally was named 
      interferon beta 2 or B cell-stimulating factor or differentiating B cell factor 
      inducing immunoglobulin production. IL-6 is produced in many diseases. After 
      secretion, IL-6 binds to its receptor IL-6R alpha (gp 80), the IL-6R alpha 
      complex then recruits the signal-transducing beta-subunit (gp 130), which is the 
      functional complex for signal transduction. In addition, activation of Th2 cells 
      or mast cells also produce IL-6, which mediates immune responses, inflammation, 
      acute phase responses, hematopoiesis, cancer, inflammatory bowel disease, etc. 
      IL-6 also is a crucial cytokine for mast cell maturation. Human cord blood CD34+ 
      cells differentiate and grow into mast cells in the presence of stem cell factor 
      (SCF) and IL-6, causing increases in cell size, frequency of chymase positive 
      cells, and intracellular histamine levels when compared with cells treated with 
      SCF alone. Activated mast cells increase IL-6 mRNA associated with protein kinase 
      C (PKC) activity. IL-6 also up-regulates histamine production rather than 
      increases its storage and is an important inducing factor for the expression of 
      immunoglobulin E (IgE) Fc epsilon RI.
FAU - Conti, Pio
AU  - Conti P
AD  - University of Chieti School of Medicine, Via dei Vestini, 66100 Chieti, Italy. 
      pconti@unich.it
FAU - Kempuraj, Duraisamy
AU  - Kempuraj D
FAU - Di Gioacchino, Mario
AU  - Di Gioacchino M
FAU - Boucher, William
AU  - Boucher W
FAU - Letourneau, Richard
AU  - Letourneau R
FAU - Kandere, Kristiana
AU  - Kandere K
FAU - Barbacane, Renato C
AU  - Barbacane RC
FAU - Reale, Marcella
AU  - Reale M
FAU - Felaco, Mario
AU  - Felaco M
FAU - Frydas, Stavros
AU  - Frydas S
FAU - Theoharides, Theoharis C
AU  - Theoharides TC
LA  - eng
PT  - Editorial
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Interleukin-6)
SB  - IM
MH  - Humans
MH  - Inflammation/*physiopathology
MH  - Interleukin-6/*physiology
MH  - Mast Cells/*physiology
EDAT- 2002/12/13 04:00
MHDA- 2003/03/13 04:00
CRDT- 2002/12/13 04:00
PHST- 2002/12/13 04:00 [pubmed]
PHST- 2003/03/13 04:00 [medline]
PHST- 2002/12/13 04:00 [entrez]
PST - ppublish
SO  - Allergy Asthma Proc. 2002 Sep-Oct;23(5):331-5.