PMID- 12478621
OWN - NLM
STAT- MEDLINE
DCOM- 20030312
LR  - 20181130
IS  - 0360-4012 (Print)
IS  - 0360-4012 (Linking)
VI  - 71
IP  - 1
DP  - 2003 Jan 1
TI  - Expression of brain-derived neurotrophic factor mRNA in rat hippocampus after 
      treatment with antipsychotic drugs.
PG  - 127-31
AB  - Typical and atypical antipsychotic drugs, though both effective, act on different 
      neurotransmitter receptors and are dissimilar in some clinical effects and side 
      effects. The typical antipsychotic drug haloperidol has been shown to cause a 
      decrease in the expression of brain-derived neurotrophic factor (BDNF), which 
      plays an important role in neuronal cell survival, differentiation, and neuronal 
      connectivity. However, it is still unknown whether atypical antipsychotic drugs 
      similarly regulate BDNF expression. We examined the effects of chronic (28 days) 
      administration of typical and atypical antipsychotic drugs on BDNF mRNA 
      expression in the rat hippocampus using in situ hybridization. Quantitative 
      analysis revealed that the typical antipsychotic drug haloperidol (1 mg/kg) 
      down-regulated BDNF mRNA expression in both CA1 (P < 0.05) and dentate gyrus (P < 
      0.01) regions compared with vehicle control. In contrast, the atypical 
      antipsychotic agents clozapine (10 mg/kg) and olanzapine (2.7 mg/kg) up-regulated 
      BDNF mRNA expression in CA1, CA3, and dentate gyrus regions of the rat 
      hippocampus compared with their respective controls (P < 0.01). These findings 
      demonstrate that the typical and atypical antipsychotic drugs differentially 
      regulate BDNF mRNA expression in rat hippocampus.
CI  - Copyright 2002 Wiley-Liss, Inc.
FAU - Bai, Ou
AU  - Bai O
AD  - Neuropsychiatry Research Unit, Department of Psychiatry, University of 
      Saskatchewan, Saskatoon, Saskatchewan, Canada.
FAU - Chlan-Fourney, Jennifer
AU  - Chlan-Fourney J
FAU - Bowen, Rudy
AU  - Bowen R
FAU - Keegan, David
AU  - Keegan D
FAU - Li, Xin-Min
AU  - Li XM
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Neurosci Res
JT  - Journal of neuroscience research
JID - 7600111
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Dopamine Agents)
RN  - 0 (RNA, Messenger)
RN  - 12794-10-4 (Benzodiazepines)
RN  - 3G0285N20N (Pirenzepine)
RN  - 46627O600J (Levodopa)
RN  - J60AR2IKIC (Clozapine)
RN  - J6292F8L3D (Haloperidol)
RN  - N7U69T4SZR (Olanzapine)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Antipsychotic Agents/*pharmacology
MH  - Benzodiazepines
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/genetics
MH  - Clozapine/pharmacology
MH  - Dopamine Agents/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Gene Expression/*drug effects
MH  - Haloperidol/pharmacology
MH  - Hippocampus/*drug effects/metabolism
MH  - In Situ Hybridization/methods
MH  - Levodopa/pharmacology
MH  - Male
MH  - Olanzapine
MH  - Pirenzepine/*analogs & derivatives/pharmacology
MH  - RNA, Messenger/drug effects/metabolism
MH  - Rats
MH  - Rats, Wistar
EDAT- 2002/12/13 04:00
MHDA- 2003/03/13 04:00
CRDT- 2002/12/13 04:00
PHST- 2002/12/13 04:00 [pubmed]
PHST- 2003/03/13 04:00 [medline]
PHST- 2002/12/13 04:00 [entrez]
AID - 10.1002/jnr.10440 [doi]
PST - ppublish
SO  - J Neurosci Res. 2003 Jan 1;71(1):127-31. doi: 10.1002/jnr.10440.