PMID- 12480036
OWN - NLM
STAT- MEDLINE
DCOM- 20030331
LR  - 20190623
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 90
IP  - 12
DP  - 2002 Dec 15
TI  - Genome scan linkage results for heart rate variability (the Framingham Heart 
      Study).
PG  - 1290-3
AB  - There is a substantial heritable component to the beat-to-beat variation in heart 
      rate. However, the molecular mechanisms underlying the control of heart rate 
      variability (HRV) remain unknown. The present study sought to identify 
      chromosomal regions linked to HRV phenotypes. The first 2 hours of ambulatory 
      electrocardiographic recordings obtained from Framingham Heart Study subjects 
      attending a routine examination were processed for HRV. HRV variables analyzed 
      included very-low-frequency power, low-frequency power, and high-frequency power. 
      Gender-specific residuals were used for log-transformed HRV data after adjustment 
      for age, HR, systolic and diastolic blood pressures, and coffee and alcohol 
      consumption. In conjunction with a 10-cM genome-wide scan, HRV data were 
      available for 725 subjects in 230 extended families, including 390 sibling pairs. 
      Variance component log-of-the-odds (LOD) scores were obtained. The highest 
      multipoint LOD scores were obtained for log very-low frequency on chromosome 15 
      at 62 cM (LOD 1.84) and for log low frequency on chromosome 2 at 153 cM (LOD 
      1.81). These data suggest there may be influential genetic regions contributing 
      to HRV. Further studies are warranted to identify genes in these regions that may 
      influence autonomic tone. Recognition of the genetic determinants of HRV may 
      provide additional insights into the pathophysiology of the autonomic nervous 
      system and offer clues to its modulation.
FAU - Singh, Jagmeet P
AU  - Singh JP
AD  - National Heart, Lung & Blood Institute's (NHLBI) Framingham Heart Study, 
      Framingham, Massachusetts 01702, USA.
FAU - Larson, Martin G
AU  - Larson MG
FAU - O'Donnell, Christopher J
AU  - O'Donnell CJ
FAU - Tsuji, Hisako
AU  - Tsuji H
FAU - Corey, Diane
AU  - Corey D
FAU - Levy, Daniel
AU  - Levy D
LA  - eng
GR  - N01-HC-38038/HC/NHLBI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Adult
MH  - Cardiovascular Diseases/*genetics
MH  - Chromosome Mapping
MH  - Chromosomes, Human, Pair 15/*genetics
MH  - Chromosomes, Human, Pair 2/*genetics
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Genetic Linkage
MH  - Genetic Markers
MH  - Genotype
MH  - Heart Rate/*genetics
MH  - Humans
MH  - Lod Score
MH  - Male
MH  - Middle Aged
MH  - Phenotype
MH  - Prospective Studies
EDAT- 2002/12/14 04:00
MHDA- 2003/04/01 05:00
CRDT- 2002/12/14 04:00
PHST- 2002/12/14 04:00 [pubmed]
PHST- 2003/04/01 05:00 [medline]
PHST- 2002/12/14 04:00 [entrez]
AID - S0002914902028655 [pii]
AID - 10.1016/s0002-9149(02)02865-5 [doi]
PST - ppublish
SO  - Am J Cardiol. 2002 Dec 15;90(12):1290-3. doi: 10.1016/s0002-9149(02)02865-5.