PMID- 12480117
OWN - NLM
STAT- MEDLINE
DCOM- 20030320
LR  - 20191106
IS  - 0924-977X (Print)
IS  - 0924-977X (Linking)
VI  - 13
IP  - 1
DP  - 2003 Jan
TI  - Chronic citalopram treatment induces time-dependent changes in the expression and 
      DNA-binding activity of transcription factor AP-2 in rat brain.
PG  - 11-7
AB  - Imbalances in the midbrain monoaminergic systems have been implicated to play a 
      role in neuropsychiatric conditions. Several genes in these systems have binding 
      sites for transcription factor activating protein-2 (AP-2) in their regulatory 
      regions. Thus, AP-2 may be a factor controlling the expression of genes in the 
      monoaminergic systems important for maintaining normal psychiatric functions. The 
      present study indicates that subchronic treatment with the antidepressant 
      citalopram induces time-dependent changes in DNA-binding activity and levels of 
      transcription factor AP-2 in rat whole brain. Rats were treated with citalopram 
      (10 mg/kg) for 1, 3, 7 and 21 days. Animals treated for 7 days had significantly 
      decreased DNA-binding activity and levels of AP-2 alpha and AP-2 beta isoforms 
      when compared to saline-treated animals. There was no observed difference between 
      citalopram- and saline-treated animals after 21 days. Elucidation of the 
      molecular mechanisms underlying mental disorders is important for future drug 
      development, where transcription factors might be important drug targets.
FAU - Berggard, C
AU  - Berggard C
AD  - Department of Neuroscience, Unit of Pharmacology, Uppsala University, PO Box 593 
      BMC, SE-751 24, Uppsala, Sweden.
FAU - Damberg, M
AU  - Damberg M
FAU - Oreland, L
AU  - Oreland L
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Eur Neuropsychopharmacol
JT  - European neuropsychopharmacology : the journal of the European College of 
      Neuropsychopharmacology
JID - 9111390
RN  - 0 (Antidepressive Agents)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factor AP-2)
RN  - 0 (Transcription Factors)
RN  - 0DHU5B8D6V (Citalopram)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Brain/*drug effects/metabolism
MH  - Citalopram/*pharmacology
MH  - DNA-Binding Proteins/analysis/*biosynthesis/genetics/metabolism
MH  - Electrophoretic Mobility Shift Assay/methods
MH  - Enzyme-Linked Immunosorbent Assay/methods
MH  - Gene Expression/*drug effects/physiology
MH  - Male
MH  - Nuclear Proteins/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Time Factors
MH  - Transcription Factor AP-2
MH  - Transcription Factors/analysis/*biosynthesis/genetics
EDAT- 2002/12/14 04:00
MHDA- 2003/03/21 04:00
CRDT- 2002/12/14 04:00
PHST- 2002/12/14 04:00 [pubmed]
PHST- 2003/03/21 04:00 [medline]
PHST- 2002/12/14 04:00 [entrez]
AID - S0924977X02000755 [pii]
AID - 10.1016/s0924-977x(02)00075-5 [doi]
PST - ppublish
SO  - Eur Neuropsychopharmacol. 2003 Jan;13(1):11-7. doi: 
      10.1016/s0924-977x(02)00075-5.