PMID- 12480128
OWN - NLM
STAT- MEDLINE
DCOM- 20030402
LR  - 20190901
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 139
IP  - 2
DP  - 2002 Dec 15
TI  - BDNF mRNA expression during postnatal development, maturation and aging of the 
      human prefrontal cortex.
PG  - 139-50
AB  - Brain derived neurotrophic factor (BDNF) is widely distributed in the central 
      nervous system (CNS) and has survival-promoting actions on a variety of CNS 
      neurons. We have examined changes in the level of BDNF mRNA expression in the 
      dorsolateral prefrontal cortex (DLPFC) of the postnatal human brain using both 
      RNAse protection assay and in situ hybridization. Expression of BDNF mRNA in the 
      DLPFC was compared to that in the occipital cortex. BDNF mRNA levels vary between 
      layers, with layer VI consistently higher than other layers in both the DLPFC and 
      occipital regions. BDNF mRNA levels increase approximately one-third from infancy 
      to adulthood, i.e. they are relatively low during infancy and adolescence, peak 
      during young adulthood, and are maintained at a constant level throughout 
      adulthood and aging. The significant increase in BDNF mRNA levels in the DLPFC 
      during the young adult period coincides with the time when the frontal cortex 
      matures both structurally and functionally. The increase in BDNF at this critical 
      time in human development may have important implications for the etiology and 
      treatment of the severe mental disorders that tend to present during this time.
FAU - Webster, Maree J
AU  - Webster MJ
AD  - Stanley Laboratory of Brain Research, Department of Psychiatry, Uniformed 
      Services University for the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 
      20814-4799, USA. websterm@stanleyresearch.org
FAU - Weickert, Cynthia Shannon
AU  - Weickert CS
FAU - Herman, Mary M
AU  - Herman MM
FAU - Kleinman, Joel E
AU  - Kleinman JE
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - EC 5.2.1.- (Cyclophilins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/genetics/*metabolism
MH  - Analysis of Variance
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cell Differentiation/genetics
MH  - Cyclophilins/genetics
MH  - Female
MH  - Gene Expression Regulation, Developmental/*genetics
MH  - Humans
MH  - Infant
MH  - Male
MH  - Neurons/cytology/*metabolism
MH  - Occipital Lobe/cytology/growth & development/metabolism
MH  - Prefrontal Cortex/cytology/*growth & development/*metabolism
MH  - RNA, Messenger/*metabolism
EDAT- 2002/12/14 04:00
MHDA- 2003/04/04 05:00
CRDT- 2002/12/14 04:00
PHST- 2002/12/14 04:00 [pubmed]
PHST- 2003/04/04 05:00 [medline]
PHST- 2002/12/14 04:00 [entrez]
AID - S0165380602005400 [pii]
AID - 10.1016/s0165-3806(02)00540-0 [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 2002 Dec 15;139(2):139-50. doi: 
      10.1016/s0165-3806(02)00540-0.