PMID- 12480261
OWN - NLM
STAT- MEDLINE
DCOM- 20031103
LR  - 20190906
IS  - 0198-8859 (Print)
IS  - 0198-8859 (Linking)
VI  - 63
IP  - 12
DP  - 2002 Dec
TI  - Blood dendritic cells and DC-poietins in systemic lupus erythematosus.
PG  - 1172-80
AB  - Dendritic cells (DCs) control immunity and tolerance. Hence, we surmised that 
      systemic lupus erythematosus (SLE), a systemic autoimmune disease with 
      autoreactive T and B cells, might be due to alterations in DC homeostasis. Taken 
      together, our results demonstrate profound alterations of DCs and DC-poietins 
      homeostasis in SLE. Elevated levels of interferon-alpha (IFN) in serum of SLE 
      patients coexist with decreased numbers of cells producing IFN-alpha, i.e., 
      plasmacytoid dendritic cells (PDCs). Decreased numbers of circulating DCs 
      correlate with increased levels of soluble tumor necrosis factor (TNF) receptors, 
      thus suggesting the potential role of TNF pathway in the observed DC alterations. 
      Finally, increased FMS-like tyrosine kinase 3-ligand (FLT3-L) and its correlation 
      with soluble TNF receptors suggest a physiologic response to compensate low DC 
      numbers. Although IFN-alpha remains at the center of immunologic aberrations in 
      SLE, it remains to be determined whether increased shedding of soluble TNF 
      receptors could also be ascribed to IFN-alpha.
FAU - Gill, Michelle A
AU  - Gill MA
AD  - Baylor Institute for Immunology Research, Dallas, Texas, USA.
FAU - Blanco, Patrick
AU  - Blanco P
FAU - Arce, Edsel
AU  - Arce E
FAU - Pascual, Virginia
AU  - Pascual V
FAU - Banchereau, Jacques
AU  - Banchereau J
FAU - Palucka, A Karolina
AU  - Palucka AK
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Interferon-alpha)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (flt3 ligand protein)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Dendritic Cells/classification/*immunology/metabolism
MH  - Flow Cytometry
MH  - Humans
MH  - Interferon-alpha/metabolism
MH  - Lupus Erythematosus, Systemic/*immunology/metabolism/pathology
MH  - Membrane Proteins/blood
MH  - Receptors, Tumor Necrosis Factor/blood
MH  - Tumor Necrosis Factor-alpha/analysis/*metabolism
EDAT- 2002/12/14 04:00
MHDA- 2003/11/05 05:00
CRDT- 2002/12/14 04:00
PHST- 2002/12/14 04:00 [pubmed]
PHST- 2003/11/05 05:00 [medline]
PHST- 2002/12/14 04:00 [entrez]
AID - S0198885902007565 [pii]
AID - 10.1016/s0198-8859(02)00756-5 [doi]
PST - ppublish
SO  - Hum Immunol. 2002 Dec;63(12):1172-80. doi: 10.1016/s0198-8859(02)00756-5.