PMID- 12481006
OWN - NLM
STAT- MEDLINE
DCOM- 20030422
LR  - 20210114
IS  - 0893-3952 (Print)
IS  - 0893-3952 (Linking)
VI  - 15
IP  - 12
DP  - 2002 Dec
TI  - Mantle cell lymphoma with 8q24 chromosomal abnormalities: a report of 5 cases 
      with blastoid features.
PG  - 1266-72
AB  - The t(11;14)(q13;q32) resulting in cyclin D1 overexpression is consistently 
      present in mantle cell lymphoma. However secondary chromosomal aberrations are 
      also extremely common. Of these, 8q24 abnormalities associated with the t(11;14) 
      are rare. Over the course of 10 years at M.D. Anderson Cancer Center, we 
      identified five cases of mantle cell lymphoma in which conventional cytogenetic 
      analysis revealed complex karyotypes, including the t(11;14) and 8q24 
      abnormalities: one with t(8;14)(q24;q32), one with t(2;8)(q13;q24), and three 
      with add(8)(q24). We performed fluorescence in situ hybridization (FISH) studies 
      on all cases. In the case with the t(8;14), IgH/myc fusion signals were 
      identified, and in the case with the t(2;8), split c-myc signals were detected. 
      In the three cases with add(8)(q24), one case had split c-myc signals and two 
      cases had three copies of c-myc. Thus, the c-myc gene was involved in all cases. 
      All five neoplasms had blastoid morphologic features, and four cases, including 
      the cases with the t(8;14) and t(2;8), had leukemic involvement. We conclude that 
      8q24 abnormalities involving the c-myc gene are uncommon secondary abnormalities 
      that occur in a subset of mantle cell lymphomas. C-myc gene abnormalities are 
      associated with blastoid cytologic features and also may be associated with 
      leukemic involvement.
FAU - Hao, Suyang
AU  - Hao S
AD  - Department of Hematopathology, The University of Texas M.D. Anderson Cancer 
      Center, Houston, Texas 77030, USA.
FAU - Sanger, Warren
AU  - Sanger W
FAU - Onciu, Mihaela
AU  - Onciu M
FAU - Lai, Raymond
AU  - Lai R
FAU - Schlette, Ellen J
AU  - Schlette EJ
FAU - Medeiros, L Jeffrey
AU  - Medeiros LJ
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Mod Pathol
JT  - Modern pathology : an official journal of the United States and Canadian Academy 
      of Pathology, Inc
JID - 8806605
RN  - 0 (Antigens, CD)
RN  - 0 (Immunoglobulin Heavy Chains)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Leukosialin)
RN  - 0 (SPN protein, human)
RN  - 0 (Sialoglycoproteins)
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Aged
MH  - *Antigens, CD
MH  - *Chromosome Aberrations
MH  - Chromosomes, Human, Pair 11/genetics
MH  - Chromosomes, Human, Pair 14/genetics
MH  - Chromosomes, Human, Pair 2/genetics
MH  - Chromosomes, Human, Pair 8/*genetics
MH  - Cyclin D1/analysis
MH  - Female
MH  - Genes, myc/genetics
MH  - Humans
MH  - Immunoglobulin Heavy Chains/genetics
MH  - Immunohistochemistry
MH  - Immunophenotyping
MH  - In Situ Hybridization, Fluorescence
MH  - Ki-67 Antigen/analysis
MH  - Leukemia/genetics/immunology/pathology
MH  - Leukosialin
MH  - Lymphoma, Mantle-Cell/genetics/immunology/*pathology
MH  - Male
MH  - Middle Aged
MH  - Sialoglycoproteins/analysis
MH  - Translocation, Genetic
RF  - 27
EDAT- 2002/12/14 04:00
MHDA- 2003/04/23 05:00
CRDT- 2002/12/14 04:00
PHST- 2002/12/14 04:00 [pubmed]
PHST- 2003/04/23 05:00 [medline]
PHST- 2002/12/14 04:00 [entrez]
AID - 10.1097/01.MP.0000037310.82136.99 [doi]
PST - ppublish
SO  - Mod Pathol. 2002 Dec;15(12):1266-72. doi: 10.1097/01.MP.0000037310.82136.99.