PMID- 12481904
OWN - NLM
STAT- MEDLINE
DCOM- 20030610
LR  - 20190816
IS  - 1042-8194 (Print)
IS  - 1026-8022 (Linking)
VI  - 43
IP  - 10
DP  - 2002 Oct
TI  - Variations in MLL amplification in a patient with acute myeloid leukemia.
PG  - 2031-5
AB  - In a 66 years old female patient with acute myeloblastic leukemia (AML) complex 
      chromosomal rearrangements involving 11q23 were diagnosed by G-banding and 
      confirmed by different fluorescence in situ hybridization (FISH) techniques. The 
      amplification of MLL gene differed in various sidelines as shown by locus 
      specific probes for 11q23 and 11q13. Complex karyotype rearrangements involving 
      deletions del(5)(q31) and del(7)(q31) were verified by multicolor fluorescence in 
      situ hybridization (mFISH).
FAU - Brezinova, Jana
AU  - Brezinova J
AD  - Institute of Hematology and Blood Transfusion, General Faculty Hospital and 1st 
      Medical Faculty, Charles University, U Nemocnice 1, 128 20, Prague, Czech 
      Republic. brez@uhkt.cz
FAU - Zemanova, Zuzana
AU  - Zemanova Z
FAU - Cermak, Jaroslav
AU  - Cermak J
FAU - Kurkova, Sarka
AU  - Kurkova S
FAU - Sindelarova, Lenka
AU  - Sindelarova L
FAU - Schwarz, Jiri
AU  - Schwarz J
FAU - Michalova, Kyra
AU  - Michalova K
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Leuk Lymphoma
JT  - Leukemia & lymphoma
JID - 9007422
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (KMT2A protein, human)
RN  - 0 (Transcription Factors)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - Aged
MH  - Chromosome Deletion
MH  - Chromosomes, Human, Pair 11
MH  - Chromosomes, Human, Pair 5
MH  - Chromosomes, Human, Pair 7
MH  - DNA-Binding Proteins/*genetics
MH  - Female
MH  - Gene Amplification/*physiology
MH  - Gene Rearrangement
MH  - Genetic Variation
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - Leukemia, Myeloid, Acute/*genetics
MH  - Myeloid-Lymphoid Leukemia Protein
MH  - *Proto-Oncogenes
MH  - *Transcription Factors
EDAT- 2002/12/17 04:00
MHDA- 2003/06/11 05:00
CRDT- 2002/12/17 04:00
PHST- 2002/12/17 04:00 [pubmed]
PHST- 2003/06/11 05:00 [medline]
PHST- 2002/12/17 04:00 [entrez]
AID - 10.1080/1042819021000015989-2 [doi]
PST - ppublish
SO  - Leuk Lymphoma. 2002 Oct;43(10):2031-5. doi: 10.1080/1042819021000015989-2.