PMID- 12482025
OWN - NLM
STAT- MEDLINE
DCOM- 20030528
LR  - 20220311
IS  - 0300-8177 (Print)
IS  - 0300-8177 (Linking)
VI  - 241
IP  - 1-2
DP  - 2002 Dec
TI  - Effect of feeding aqueous extract of Pterocarpus marsupium on glycogen content of 
      tissues and the key enzymes of carbohydrate metabolism.
PG  - 53-9
AB  - The Indian traditional system of medicine prescribed plant therapies for diseases 
      including diabetes mellitus called madhumeh in Sanskrit. One such plant mentioned 
      in Ayurveda is Pterocarpus marsupium (PM). In the present study, aqueous extract 
      of PM (1 g/kg PO) was assessed for its effect on glycogen levels of insulin 
      dependent (skeletal muscle and liver), insulin-independent tissues (kidneys and 
      brain) and enzymes such as glucokinase (GK), hexokinase (HK), and 
      phosphofructokinase (PFK). Administration of PM led to decrease in blood glucose 
      levels by 38 and 60% on 15th and 30th day of the experiment. Liver and 2-kidney 
      weight expressed as percentage of body-weight was significantly increased in 
      diabetics (p < 0.0005) vs. normal controls and this alteration in the renal 
      weight (p < 0.0005) but not liver weight was normalized by feeding of PM extract. 
      Renal glycogen content increased by over 10-fold while hepatic and skeletal 
      muscle glycogen content decreased by 75 and 68% in diabetic controls vs. controls 
      and these alteration in glycogen content was partly prevented by PM. Activity of 
      HK, GK and PFK in diabetic controls was 35,50 and 60% of the controls and PM 
      completely corrected this alteration in PFK and only partly in HK and GK.
FAU - Grover, Jagdish Kumari
AU  - Grover JK
AD  - Department of Pharmacology, All India Institute of Medical Sciences, Ansari 
      Nagar, New Delhi, India. jkgrover@hotmail.com
FAU - Vats, Vikrant
AU  - Vats V
FAU - Yadav, Satyapal
AU  - Yadav S
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Plant Extracts)
RN  - 9005-79-2 (Glycogen)
RN  - EC 2.7.1 - (Phosphofructokinases)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.2 (Glucokinase)
SB  - IM
MH  - Animals
MH  - Body Weight/drug effects
MH  - *Carbohydrate Metabolism
MH  - Glucokinase/metabolism
MH  - Glycogen/*metabolism
MH  - Hexokinase/metabolism
MH  - Kidney/drug effects/enzymology
MH  - Liver/drug effects/enzymology
MH  - Male
MH  - Organ Size/drug effects
MH  - Phosphofructokinases/metabolism
MH  - Plant Extracts/*administration & dosage/pharmacology
MH  - Pterocarpus/*chemistry
MH  - Rats
EDAT- 2002/12/17 04:00
MHDA- 2003/05/29 05:00
CRDT- 2002/12/17 04:00
PHST- 2002/12/17 04:00 [pubmed]
PHST- 2003/05/29 05:00 [medline]
PHST- 2002/12/17 04:00 [entrez]
AID - 10.1023/a:1020870526014 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2002 Dec;241(1-2):53-9. doi: 10.1023/a:1020870526014.