PMID- 12482915
OWN - NLM
STAT- MEDLINE
DCOM- 20030822
LR  - 20190607
IS  - 0021-9533 (Print)
IS  - 0021-9533 (Linking)
VI  - 116
IP  - Pt 2
DP  - 2003 Jan 15
TI  - Lipopolysaccharides from Legionella and Rhizobium stimulate mouse bone marrow 
      granulocytes via Toll-like receptor 2.
PG  - 293-302
AB  - Lipopolysaccharide (LPS) derived from enterobacteria elicit in several cell types 
      cellular responses that are restricted in the use of Toll-like receptor 4 (TLR4) 
      as the principal signal-transducing molecule. A tendency to consider 
      enterobacterial LPS as a prototypic LPS led some authors to present this 
      mechanism as a paradigm accounting for all LPSs in all cell types. However, the 
      structural diversity of LPS does not allow such a general statement. By using 
      LPSs from bacteria that do not belong to the Enterobacteriaceae, we show that in 
      bone marrow cells (BMCs) the LPS of Rhizobium species Sin-1 and of three strains 
      of Legionella pneumophila require TLR2 rather than TLR4 to elicit the expression 
      of CD14. In addition, exposure of BMCs from TLR4-deficient (C3H/HeJ) mice to the 
      lipid A fragment of the Bordetella pertussis LPS inhibits their activation by the 
      Legionella lipid A. The data show selective action of different LPSs via 
      different TLRs, and suggest that TLR2 can interact with many lipid A structures, 
      leading to either agonistic or specific antagonistic effects.
FAU - Girard, Robert
AU  - Girard R
AD  - Lymphocyte development, URA-1961 of the National Center for Scientific Research, 
      Pasteur Institute, Paris, France.
FAU - Pedron, Thierry
AU  - Pedron T
FAU - Uematsu, Satoshi
AU  - Uematsu S
FAU - Balloy, Viviane
AU  - Balloy V
FAU - Chignard, Michel
AU  - Chignard M
FAU - Akira, Shizuo
AU  - Akira S
FAU - Chaby, Richard
AU  - Chaby R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Cell Sci
JT  - Journal of cell science
JID - 0052457
RN  - 0 (Lipid A)
RN  - 0 (Lipopolysaccharide Receptors)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Animals
MH  - Chemotaxis, Leukocyte/drug effects/*immunology
MH  - Gram-Negative Bacterial Infections/*immunology/metabolism
MH  - Granulocytes/drug effects/*immunology
MH  - Legionella pneumophila/immunology/metabolism
MH  - Lipid A/immunology/pharmacology
MH  - Lipopolysaccharide Receptors/immunology
MH  - Lipopolysaccharides/*immunology/pharmacology
MH  - Membrane Glycoproteins/deficiency/genetics/immunology/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Receptors, Cell Surface/deficiency/genetics/immunology/metabolism
MH  - Rhizobium/immunology/metabolism
MH  - Toll-Like Receptor 2
MH  - Toll-Like Receptor 4
MH  - Toll-Like Receptors
EDAT- 2002/12/17 04:00
MHDA- 2003/08/23 05:00
CRDT- 2002/12/17 04:00
PHST- 2002/12/17 04:00 [pubmed]
PHST- 2003/08/23 05:00 [medline]
PHST- 2002/12/17 04:00 [entrez]
AID - 10.1242/jcs.00212 [doi]
PST - ppublish
SO  - J Cell Sci. 2003 Jan 15;116(Pt 2):293-302. doi: 10.1242/jcs.00212.