PMID- 12483209
OWN - NLM
STAT- MEDLINE
DCOM- 20030213
LR  - 20141120
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 4
IP  - 1
DP  - 2003 Jan
TI  - Essential role of Id2 in negative regulation of IgE class switching.
PG  - 25-30
AB  - Serum concentrations of immunoglobulin E (IgE) in normal circumstances are kept 
      much lower than those of other Ig isotypes to avoid allergic reactions. B cells 
      lacking Id2 have increased E2A activity, which leads to specific enhancement of 
      germline transcription of the immunoglobulin epsilon locus. As a consequence, 
      Id2-deficient B cells undergo class switch recombination (CSR) to IgE at a much 
      higher frequency than wild-type B cells. In contrast, Id2 is induced in wild-type 
      B cells by transforming growth factor-beta1 (TGF-beta1) and suppresses IgE CSR. 
      Our results provide evidence for the inhibitory and selective role of Id2 in IgE 
      CSR in response to TGF-beta1. Id2 might act as molecular safeguard to suppress 
      IgE CSR to prevent serious complications such as allergic hypersensitivity during 
      the normal course of immune responses.
FAU - Sugai, Manabu
AU  - Sugai M
AD  - Center for Molecular Biology and Genetics, Kyoto University, 
      Shogoin-Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan.
FAU - Gonda, Hiroyuki
AU  - Gonda H
FAU - Kusunoki, Takashi
AU  - Kusunoki T
FAU - Katakai, Tomoya
AU  - Katakai T
FAU - Yokota, Yoshifumi
AU  - Yokota Y
FAU - Shimizu, Akira
AU  - Shimizu A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20021216
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (ID2 protein, human)
RN  - 0 (Idb2 protein, mouse)
RN  - 0 (Inhibitor of Differentiation Protein 2)
RN  - 0 (Repressor Proteins)
RN  - 0 (TCF3 protein, human)
RN  - 0 (TGFB1 protein, human)
RN  - 0 (Tgfb1 protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 0 (Transforming Growth Factor beta)
RN  - 0 (Transforming Growth Factor beta1)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9007-49-2 (DNA)
SB  - IM
CIN - Nat Immunol. 2003 Jan;4(1):7-8. PMID: 12496968
MH  - Animals
MH  - B-Lymphocytes/drug effects/immunology
MH  - Base Sequence
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - DNA/genetics/metabolism
MH  - DNA-Binding Proteins/*genetics/*metabolism
MH  - Humans
MH  - Hypersensitivity/genetics/immunology
MH  - *Immunoglobulin Class Switching/drug effects
MH  - Immunoglobulin E/*biosynthesis/*genetics
MH  - In Vitro Techniques
MH  - Inhibitor of Differentiation Protein 2
MH  - Mice
MH  - Mice, Knockout
MH  - Promoter Regions, Genetic
MH  - Protein Binding
MH  - *Repressor Proteins
MH  - Transcription Factors/*genetics/*metabolism
MH  - Transcriptional Activation
MH  - Transforming Growth Factor beta/pharmacology
MH  - Transforming Growth Factor beta1
EDAT- 2002/12/17 04:00
MHDA- 2003/02/14 04:00
CRDT- 2002/12/17 04:00
PHST- 2002/08/25 00:00 [received]
PHST- 2002/10/23 00:00 [accepted]
PHST- 2002/12/17 04:00 [pubmed]
PHST- 2003/02/14 04:00 [medline]
PHST- 2002/12/17 04:00 [entrez]
AID - ni874 [pii]
AID - 10.1038/ni874 [doi]
PST - ppublish
SO  - Nat Immunol. 2003 Jan;4(1):25-30. doi: 10.1038/ni874. Epub 2002 Dec 16.