PMID- 12485196
OWN - NLM
STAT- MEDLINE
DCOM- 20031104
LR  - 20190816
IS  - 0009-9163 (Print)
IS  - 0009-9163 (Linking)
VI  - 62
IP  - 6
DP  - 2002 Dec
TI  - Association between G-308A polymorphism of the tumor necrosis factor-alpha gene 
      and 24-hour ambulatory blood pressure values in type 1 diabetic adolescents.
PG  - 474-7
AB  - Tumor necrosis factor-alpha (TNF-alpha) is an inflammatory cytokine, which also 
      influences blood pressure (BP). The G-308A polymorphism of the TNF-alpha gene is 
      associated with altered TNF-alpha production. The prevalence of the 
      TNF-alpha-308A allele is reportedly higher among patients with type 1 diabetes 
      mellitus (T1DM) than in the healthy population. In this study we investigated 
      whether this genetic polymorphism might correlate with BP values in diabetic 
      adolescents. Ambulatory BP monitoring (ABPM) was performed in 126 adolescents 
      with T1DM (mean age: 14 +/- 2.4 years). The TNF-alpha G-308A genotype was 
      determined by using polymerase chain reaction (PCR) and restriction fragment 
      length polymorphism (RFLP) methodologies. ABPM results were related to healthy 
      reference values and are given as standard deviation score (SDS). The prevalence 
      of the -308A allele was higher in diabetic adolescents than the Hungarian 
      reference population (0.26 vs 0.14, p < 0.01). TNF-alpha genotype was associated 
      both with systolic and diastolic BP values (p < 0.01 and p < 0.01, respectively). 
      In patients with TNF-alpha-308GG and -308GA/AA genotypes, the 24-h systolic BP 
      average values were 0.37 +/- 1.33 and -0.38 +/- 1.28 SDS, while 24-h diastolic BP 
      average values were 0.09 +/- 1.30 and -0.67 +/- 1.31 SDS. Hence, the 
      TNF-alpha-308A allele carrier state appears to be associated with lower systolic 
      and diastolic BP values.
FAU - Krikovszky, D
AU  - Krikovszky D
AD  - First Department of Paediatrics, Semmelweis University, Budapest, Hungary. 
      hecsito@axelero.hu
FAU - Vasarhelyi, B
AU  - Vasarhelyi B
FAU - Toth-Heyn, P
AU  - Toth-Heyn P
FAU - Korner, A
AU  - Korner A
FAU - Tulassay, T
AU  - Tulassay T
FAU - Madacsy, L
AU  - Madacsy L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Clin Genet
JT  - Clinical genetics
JID - 0253664
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Blood Pressure/genetics
MH  - *Blood Pressure Monitoring, Ambulatory
MH  - Child
MH  - DNA Mutational Analysis
MH  - Diabetes Mellitus, Type 1/*genetics/*physiopathology
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Hungary/epidemiology
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2002/12/18 04:00
MHDA- 2003/11/05 05:00
CRDT- 2002/12/18 04:00
PHST- 2002/12/18 04:00 [pubmed]
PHST- 2003/11/05 05:00 [medline]
PHST- 2002/12/18 04:00 [entrez]
AID - cge620609 [pii]
AID - 10.1034/j.1399-0004.2002.620609.x [doi]
PST - ppublish
SO  - Clin Genet. 2002 Dec;62(6):474-7. doi: 10.1034/j.1399-0004.2002.620609.x.