PMID- 12485317
OWN - NLM
STAT- MEDLINE
DCOM- 20030725
LR  - 20220330
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 13
IP  - 6
DP  - 2002 Dec
TI  - Wheezing requiring hospitalization in early childhood: predictive factors for 
      asthma in a six-year follow-up.
PG  - 418-25
AB  - Although asthma is common after wheezing in early childhood, the risk factors for 
      and the prevention of later asthma are poorly understood. During the present 
      follow-up study, a range of possible predictive factors for school-age asthma was 
      evaluated. The study group consisted of 82 children hospitalized for wheezing at 
      age < 2 years in 1992-93. The baseline data were collected on entry to the study. 
      In 1999, the children were re-examined at the median age of 7.2 years. A 
      structured questionnaire was applied to chart the symptoms suggestive of asthma, 
      and the children were examined clinically. An exercise challenge test, as well as 
      skin prick tests (SPT) to common inhalant allergens, was performed. Asthma was 
      present in 33 (40%) children, 30 (91%) having continuous medication for asthma. 
      The significant asthma-predictive factors, present on entry to the study, were 
      blood eosinophilia (p = 0.0008), atopic dermatitis (p = 0.0089), elevated total 
      serum immunoglobulin E (IgE) (p = 0.0452), and a history of earlier episodes of 
      wheezing in infancy (p = 0.0468). SPT positivity in early childhood was also 
      associated with school-age asthma (p = 0.002). In contrast, respiratory syncytial 
      virus (RSV) identification during the index episode of wheezing played a minor 
      role as a predictive factor for asthma. In conclusion, if hospitalization for 
      wheezing occurs in infancy, more than every third child will suffer from asthma 
      at early school age; the risk is significantly increased with recurrent wheezing 
      in infancy and the development of allergic manifestations.
FAU - Kotaniemi-Syrjanen, Anne
AU  - Kotaniemi-Syrjanen A
AD  - Kuopio University Hospital, Department of Paediatrics, Finland. 
      kotaniem@hytti.uku.fi
FAU - Reijonen, Tiina M
AU  - Reijonen TM
FAU - Korhonen, Kaj
AU  - Korhonen K
FAU - Korppi, Matti
AU  - Korppi M
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 0 (Anti-Asthmatic Agents)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Air Pollution, Indoor/adverse effects
MH  - Allergens/adverse effects
MH  - Anti-Asthmatic Agents/therapeutic use
MH  - Asthma/blood/*diagnosis/etiology
MH  - Dermatitis, Atopic/blood/etiology/therapy
MH  - Eosinophils/metabolism
MH  - Exercise Test
MH  - Follow-Up Studies
MH  - *Hospitalization
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Infant Welfare
MH  - Leukocyte Count
MH  - Predictive Value of Tests
MH  - *Respiratory Sounds
MH  - Respiratory Syncytial Virus Infections/blood/etiology/therapy
MH  - Risk Factors
MH  - Skin Tests
EDAT- 2002/12/18 04:00
MHDA- 2003/07/26 05:00
CRDT- 2002/12/18 04:00
PHST- 2002/12/18 04:00 [pubmed]
PHST- 2003/07/26 05:00 [medline]
PHST- 2002/12/18 04:00 [entrez]
AID - 2o091 [pii]
AID - 10.1034/j.1399-3038.2002.02091.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2002 Dec;13(6):418-25. doi: 
      10.1034/j.1399-3038.2002.02091.x.