PMID- 12485320
OWN - NLM
STAT- MEDLINE
DCOM- 20030725
LR  - 20191106
IS  - 0905-6157 (Print)
IS  - 0905-6157 (Linking)
VI  - 13
IP  - 6
DP  - 2002 Dec
TI  - Immunoglobulin G antibodies of children exposed to microorganisms in a 
      water-damaged school.
PG  - 438-42
AB  - The aim of this study was to determine whether exposure to fungi (molds and 
      yeasts) among children attending a water-damaged school was reflected by the 
      children's immunoglobulin G (IgG) response to microorganisms typical of water 
      damage and whether the presence of these IgG antibodies was associated with 
      respiratory symptoms and morbidity. The relationships between positive IgG 
      antibodies and atopy, described as elevated allergen-specific immunoglobulin E 
      (IgE) antibodies, were also examined. The study population consisted of a 
      randomly selected group of exposed children attending a water-damaged school and 
      a group of unexposed children of the same age. Serum samples for analyses of IgG 
      and IgE antibodies were drawn from the children. The respiratory morbidity, the 
      number of positive IgG antibodies to nine microorganisms indicating water damage, 
      and IgE sensitization to common environmental allergens (Phadiatop) were studied. 
      The mean number of positive IgG findings was significantly higher among the 
      exposed children. The number of positive IgG antibodies did not correlate with 
      respiratory illnesses or symptoms at the individual level even though the exposed 
      children who had positive IgG antibodies to four or more microorganisms in the 
      total group comparison tended to have higher respiratory morbidity. In the 
      exposed group, a negative correlation was found between the number of positive 
      IgG antibodies and the total value of allergen-specific IgE antibodies. As among 
      adults exposed to microorganisms at work, IgG antibodies in children seem to be a 
      relevant indicator of exposure to microorganisms in a water-damaged school on the 
      group level.
FAU - Savilahti, Risto
AU  - Savilahti R
AD  - Lahti Health Center, City of Lahti, Finland. Risto.Savilahti@Lahti.fi
FAU - Uitti, Jukka
AU  - Uitti J
FAU - Laippala, Pekka
AU  - Laippala P
FAU - Husman, Tuula
AU  - Husman T
FAU - Reiman, Marjut
AU  - Reiman M
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (anti-IgG)
RN  - 059QF0KO0R (Water)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/adverse effects/classification/immunology
MH  - Antibodies, Anti-Idiotypic/*blood
MH  - Antibody Specificity/*immunology
MH  - Child
MH  - Child Welfare
MH  - Environmental Exposure/*adverse effects/classification
MH  - Environmental Pollution/*analysis
MH  - Finland/epidemiology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Prevalence
MH  - Respiratory Hypersensitivity/immunology/microbiology
MH  - School Health Services
MH  - Statistics as Topic
MH  - Surveys and Questionnaires
MH  - Water/*adverse effects
MH  - *Water Microbiology
EDAT- 2002/12/18 04:00
MHDA- 2003/07/26 05:00
CRDT- 2002/12/18 04:00
PHST- 2002/12/18 04:00 [pubmed]
PHST- 2003/07/26 05:00 [medline]
PHST- 2002/12/18 04:00 [entrez]
AID - 2o071 [pii]
AID - 10.1034/j.1399-3038.2002.02071.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2002 Dec;13(6):438-42. doi: 
      10.1034/j.1399-3038.2002.02071.x.