PMID- 12486224
OWN - NLM
STAT- MEDLINE
DCOM- 20030121
LR  - 20181113
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 99
IP  - 26
DP  - 2002 Dec 24
TI  - ARF mutation accelerates pituitary tumor development in Rb+/- mice.
PG  - 16865-70
AB  - Mice heterozygous for the retinoblastoma (Rb) tumor suppressor gene develop 
      pituitary and thyroid tumors with high penetrance. We demonstrate here that loss 
      of the ARF tumor suppressor strongly accelerates intermediate lobe pituitary 
      tumorigenesis in Rb heterozygous mice. These effects in the pituitary are greater 
      than those conferred by p53 loss in that Rb+-;ARF-- mice display significantly 
      more early atypical lesions than Rb+-; p53-- mice. Also, Rb+-;ARF-- compound 
      mutants do not develop many of the novel tumors or precancerous lesions seen in 
      Rb+-;p53-- compound mutants. Although complete loss of ARF expression is not 
      obligatory for pituitary tumorigenesis in Rb+- mice, alterations of the ARF locus 
      are observed in tumors from Rb+-;ARF+- mice, consistent with a selective 
      advantage of ARF inactivation in this context. We conclude that inactivation of 
      ARF acts more broadly than that of p53 in connecting abrogation of the Rb pathway 
      to tumorigenesis.
FAU - Tsai, Kenneth Y
AU  - Tsai KY
AD  - Department of Biology and Center for Cancer Research, and Howard Hughes Medical 
      Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
FAU - MacPherson, David
AU  - MacPherson D
FAU - Rubinson, Douglas A
AU  - Rubinson DA
FAU - Nikitin, Alexander Yu
AU  - Nikitin AY
FAU - Bronson, Roderick
AU  - Bronson R
FAU - Mercer, Kim L
AU  - Mercer KL
FAU - Crowley, Denise
AU  - Crowley D
FAU - Jacks, Tyler
AU  - Jacks T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20021216
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Tumor Suppressor Protein p14ARF)
SB  - IM
CIN - Cell Cycle. 2003 Jan-Feb;2(1):27-30. PMID: 12695682
MH  - Animals
MH  - Cell Division
MH  - Chromosome Mapping
MH  - Genes, Retinoblastoma/*physiology
MH  - Genes, p53/physiology
MH  - Loss of Heterozygosity
MH  - Mice
MH  - *Mutation
MH  - Pituitary Neoplasms/*genetics/pathology
MH  - Tumor Suppressor Protein p14ARF/*genetics
PMC - PMC139235
EDAT- 2002/12/18 04:00
MHDA- 2003/01/22 04:00
PMCR- 2003/06/24
CRDT- 2002/12/18 04:00
PHST- 2002/12/18 04:00 [pubmed]
PHST- 2003/01/22 04:00 [medline]
PHST- 2002/12/18 04:00 [entrez]
PHST- 2003/06/24 00:00 [pmc-release]
AID - 262499599 [pii]
AID - pq2602016865 [pii]
AID - 10.1073/pnas.262499599 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16865-70. doi: 
      10.1073/pnas.262499599. Epub 2002 Dec 16.