PMID- 12487832
OWN - NLM
STAT- MEDLINE
DCOM- 20030926
LR  - 20041117
IS  - 0888-0018 (Print)
IS  - 0888-0018 (Linking)
VI  - 19
IP  - 8
DP  - 2002 Dec
TI  - Red blood cell indexes in patients in patients with hereditary spherocytosis and 
      beta-thalassemia combination.
PG  - 569-73
AB  - The spontaneous occurrence of hereditary spherocytosis (HS) and beta-thalassemia 
      in the same patient is a rare event. The mean corpuscular hemoglobin 
      concentration is elevated above the reference range in half to two-thirds of 
      patients with HS, but there are no data for the HS/beta-thal combinations for the 
      red blood cell indexes. This study reassessed these values in these particular 
      patients. Hemoglobin, hematocrit, mean corpuscular volume (MCV), mean corpuscular 
      hemoglobin concentration (MCHC), red cell distribution (RDW), and reticulocyte 
      count were documented from 43 HS patients, 13 of which were from 10 families with 
      the combination of beta-thal and HS; 28 controls were also included. Patients 
      with HS/beta-thal have a significantly lower MCV, mean corpuscular hemoglobin, 
      and MCHC and a significantly higher RDW than normal control subjects; 95% of 
      beta-thalassemia carriers are free of clinical symptoms. When red blood cell 
      indexes reveal a possibility of a beta-thalassemia carrier state with the 
      symptoms of hemolytic anemia, HS should be considered.
FAU - Akar, Nejat
AU  - Akar N
AD  - Paediatric Molecular Genetics Department, Ankara University, Ankara, Turkey. 
      nejatakar@hotmail.com
FAU - Gokce, Hafize
AU  - Gokce H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Pediatr Hematol Oncol
JT  - Pediatric hematology and oncology
JID - 8700164
RN  - 0 (Hemoglobins)
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - DNA Mutational Analysis
MH  - Erythrocyte Indices/*physiology
MH  - Family Health
MH  - Hematologic Tests
MH  - Hemoglobins/analysis
MH  - Humans
MH  - Mutation
MH  - Spherocytosis, Hereditary/blood/*complications/genetics
MH  - beta-Thalassemia/blood/*complications/genetics
EDAT- 2002/12/19 04:00
MHDA- 2003/09/27 05:00
CRDT- 2002/12/19 04:00
PHST- 2002/12/19 04:00 [pubmed]
PHST- 2003/09/27 05:00 [medline]
PHST- 2002/12/19 04:00 [entrez]
AID - 10.1080/08880010290097431 [doi]
PST - ppublish
SO  - Pediatr Hematol Oncol. 2002 Dec;19(8):569-73. doi: 10.1080/08880010290097431.