PMID- 12488824 OWN - NLM STAT- MEDLINE DCOM- 20030415 LR - 20231213 IS - 0959-4965 (Print) IS - 0959-4965 (Linking) VI - 13 IP - 17 DP - 2002 Dec 3 TI - Effect of the novel sigma1 receptor ligand and putative atypical antipsychotic E-5842 on BDNF mRNA expression in the rat brain. PG - 2345-8 AB - Changes in the expression of brain-derived neurotrophic factor (BDNF) have been implicated in some neuropsychiatric disorders. Several antipsychotic drugs affect the expression of BDNF mRNA in different areas of the rat brain. We examined the effect of single or repeated administration of 4-[4-fluorophenyl]-1,2,3,6-tetra-hydo-1-[4-[1,-2,4-triazol-1-il]butyl]pyridine citrate) (E-5842), a sigma1 receptor ligand and putative atypical antipsychotic drug on the expression of BDNF mRNA in rats. Acute treatment with E-5842 induced a down-regulation of BDNF mRNA levels in the frontal cortex and hippocampus, while a chronic treatment had no effect. Levels of another neurotrophin, nerve growth factor (NGF), remained unaltered after either acute or chronic treatment. The effects suggest that any therapeutic properties of E-5842 are not mediated by stimulation of BDNF or NGF, whereas the regulation of these trophic factors may be part of the mechanism of action of sigma1 receptor ligands. FAU - Ovalle, Sergio AU - Ovalle S AD - Department of Neuropharmacology, Research Center, Esteve, S.A., Verge de Montserrat 221, 08041-Barcelona, Spain. FAU - Andreu, Francesc AU - Andreu F FAU - Perez, M Pilar AU - Perez MP FAU - Zamanillo, Daniel AU - Zamanillo D FAU - Guitart, Xavier AU - Guitart X LA - eng PT - Journal Article PL - England TA - Neuroreport JT - Neuroreport JID - 9100935 RN - 0 (Antipsychotic Agents) RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (E 5842) RN - 0 (Pyridines) RN - 0 (RNA, Messenger) RN - 0 (Receptors, sigma) RN - 0 (Triazoles) RN - 9061-61-4 (Nerve Growth Factor) SB - IM MH - Animals MH - Antipsychotic Agents/*pharmacology MH - Brain/*drug effects/metabolism MH - Brain-Derived Neurotrophic Factor/*genetics MH - Down-Regulation/drug effects/physiology MH - Frontal Lobe/drug effects/metabolism MH - Hippocampus/drug effects/metabolism MH - Male MH - Neostriatum/drug effects/metabolism MH - Nerve Growth Factor/genetics MH - Neurocognitive Disorders/*drug therapy/metabolism/physiopathology MH - Neurons/*drug effects/metabolism MH - Pyridines/*pharmacology MH - RNA, Messenger/drug effects/metabolism MH - Rats MH - Rats, Sprague-Dawley MH - Receptors, sigma/*drug effects/metabolism MH - Synaptic Transmission/drug effects/physiology MH - Triazoles/*pharmacology MH - Sigma-1 Receptor EDAT- 2002/12/19 04:00 MHDA- 2003/04/16 05:00 CRDT- 2002/12/19 04:00 PHST- 2002/12/19 04:00 [pubmed] PHST- 2003/04/16 05:00 [medline] PHST- 2002/12/19 04:00 [entrez] AID - 10.1097/00001756-200212030-00035 [doi] PST - ppublish SO - Neuroreport. 2002 Dec 3;13(17):2345-8. doi: 10.1097/00001756-200212030-00035.