PMID- 12490566
OWN - NLM
STAT- MEDLINE
DCOM- 20030314
LR  - 20190607
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 130
IP  - 3
DP  - 2003 Feb
TI  - Differential effects of cortical neurotrophic factors on development of lateral 
      geniculate nucleus and superior colliculus neurons: anterograde and retrograde 
      actions.
PG  - 611-22
AB  - Neurotrophins strongly affect visual system development and plasticity. However, 
      the mode of delivery and targets of neurotrophin action are still under debate. 
      For instance, cortical NT-4/5 (neurotrophin 4/5; Ntf4/5) was shown to rescue 
      lateral geniculate nucleus (LGN) neurons from monocular deprivation-induced 
      atrophy suggesting a retrograde action on thalamic afferents. It is still unclear 
      whether LGN neurons respond to NT-4/5 and other neurotrophins during development 
      in animals with normal vision. We now show that infusions of NT-4/5 and NGF 
      (nerve growth factor) into visual cortex at the onset and the peak of the 
      critical period accelerated LGN neuron growth. BDNF (brain-derived neurotrophic 
      factor) was ineffective. The effects of neurotrophin on LGN development were 
      clearly dissociated from the effects at cortical level because soma growth of 
      cortical layer IV and VI neurons was strongly promoted by BDNF. NT-4/5 was only 
      effective at the onset, but no longer at the peak of the critical period 
      suggesting a switch in neurotrophin dependency for these cortical cell classes. 
      To dissociate retrograde and anterograde effects of the TrkB ligands, we analyzed 
      the stratum griseum superficiale (SGS) of the superior colliculus, a target of 
      visual cortical efferents. Indeed, TrkB-expressing inhibitory SGS neurons 
      responded to cortical NT-4/5 infusion with somatic growth. Strikingly, the 
      TrkB-expressing excitatory tectothalamic calbindin neurons in the SGS did not 
      respond. This demonstrated for the first time a selective cell type-specific 
      anterograde action of NT-4/5 and suggested for the LGN that anterograde as well 
      as retrograde effects contribute to soma size regulation. Strikingly, cortical 
      infusion of the cytokine LIF, which affects development of visual cortex 
      neurochemical architecture, transiently inhibited growth of neurons in LGN, 
      cortical layer IV and VI and SGS. In summary, the study presents three important 
      results. First, central neurons regulate soma size development in an age-and 
      ligand-specific fashion. Second, NT-4/5 and NGF accelerate LGN development in 
      rats with normal vision while LIF delays growth. Third, anterogradely transported 
      NT-4/5 effectively promotes neuronal maturation. These differential actions on 
      subcortical neurons may contribute to the different effects of neurotrophins on 
      visual system development and plasticity.
FAU - Wahle, Petra
AU  - Wahle P
AD  - AG Entwicklungsneurobiologie ND 6/72, Fakultat fur Biologie, Ruhr-Universitat, 
      44780 Bochum, Germany. wahle@neurobiologie.ruhr-uni-bochum.de
FAU - Di Cristo, Graziella
AU  - Di Cristo G
FAU - Schwerdtfeger, Gudrun
AU  - Schwerdtfeger G
FAU - Engelhardt, Maren
AU  - Engelhardt M
FAU - Berardi, Nicoletta
AU  - Berardi N
FAU - Maffei, Lamberto
AU  - Maffei L
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Growth Inhibitors)
RN  - 0 (Interleukin-6)
RN  - 0 (Leukemia Inhibitory Factor)
RN  - 0 (Lymphokines)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Recombinant Proteins)
RN  - 145172-44-7 (neurotrophin 5)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Afferent Pathways/cytology/drug effects/growth & development
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/pharmacology
MH  - Cell Size/drug effects
MH  - Efferent Pathways/cytology/drug effects/growth & development
MH  - Geniculate Bodies/cytology/*drug effects/*growth & development
MH  - Growth Inhibitors/pharmacology
MH  - *Interleukin-6
MH  - Leukemia Inhibitory Factor
MH  - Lymphokines/pharmacology
MH  - Nerve Growth Factors/*pharmacology
MH  - Neuronal Plasticity/drug effects
MH  - Neurons/drug effects
MH  - Rats
MH  - Rats, Long-Evans
MH  - Recombinant Proteins/pharmacology
MH  - Superior Colliculi/cytology/*drug effects/*growth & development
MH  - Visual Cortex/cytology/drug effects/growth & development
MH  - Visual Pathways/cytology/drug effects/growth & development
EDAT- 2002/12/20 04:00
MHDA- 2003/03/15 04:00
CRDT- 2002/12/20 04:00
PHST- 2002/12/20 04:00 [pubmed]
PHST- 2003/03/15 04:00 [medline]
PHST- 2002/12/20 04:00 [entrez]
AID - 10.1242/dev.00224 [doi]
PST - ppublish
SO  - Development. 2003 Feb;130(3):611-22. doi: 10.1242/dev.00224.