PMID- 12490800
OWN - NLM
STAT- MEDLINE
DCOM- 20030117
LR  - 20221207
IS  - 0041-1337 (Print)
IS  - 0041-1337 (Linking)
VI  - 74
IP  - 11
DP  - 2002 Dec 15
TI  - HLA matching and the United Network for Organ Sharing Allocation System: impact 
      of HLA matching on African-American recipients of cadaveric kidney transplants.
PG  - 1634-6
AB  - BACKGROUND: A recent proposal supports the elimination of allocation points for 
      human leukocyte antigen (HLA) mismatches (MM) in cadaveric kidney 
      transplantation. The intent is to increase access for some racial groups that 
      might be disadvantaged by the representation of race-specific HLA in a largely 
      white donor pool. We report our experience from two transplant centers that serve 
      a large African American (AA) patient population. METHODS: All cadaveric 
      transplants into AA recipients from 1994 to 2000 (n=162) were included in a 
      retrospective review. RESULTS: Superior graft survival was observed in AA 
      recipients of 0 MM transplants. When induction therapy was used, the graft 
      survival at 3 years for the human leukocyte antigen (HLA)-BDR MM grades given 
      allocation points (0,1,2 MM) was 82% versus only 49% for BDR MM grades not given 
      points (3,4 MM: =0.0022). CONCLUSIONS: Our collective experience demonstrates 
      that AA patients having HLA-BDR MM grades given allocation points had better 
      graft survival. Removing points for HLA from the national allocation system may 
      result in significantly poorer outcome in AA kidney recipients.
FAU - Rebellato, Lorita M
AU  - Rebellato LM
AD  - East Carolina University Brody School of Medicine, Department of Pathology, 
      Greenville, NC, USA.
FAU - Arnold, Angelo N
AU  - Arnold AN
FAU - Bozik, Karen M
AU  - Bozik KM
FAU - Haisch, Carl E
AU  - Haisch CE
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - United States
TA  - Transplantation
JT  - Transplantation
JID - 0132144
SB  - IM
CON - Transplantation. 2002 Dec 15;74(11):1505-6. PMID: 12494957
MH  - Adolescent
MH  - Adult
MH  - Black or African American
MH  - Aged
MH  - *Black People
MH  - *Cadaver
MH  - Child
MH  - Female
MH  - Graft Survival
MH  - *Histocompatibility Testing
MH  - Humans
MH  - *Kidney Transplantation
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - *Tissue Donors
MH  - *Tissue and Organ Procurement
EDAT- 2002/12/20 04:00
MHDA- 2003/01/18 04:00
CRDT- 2002/12/20 04:00
PHST- 2002/12/20 04:00 [pubmed]
PHST- 2003/01/18 04:00 [medline]
PHST- 2002/12/20 04:00 [entrez]
AID - 10.1097/00007890-200212150-00024 [doi]
PST - ppublish
SO  - Transplantation. 2002 Dec 15;74(11):1634-6. doi: 
      10.1097/00007890-200212150-00024.