PMID- 12492714
OWN - NLM
STAT- MEDLINE
DCOM- 20030618
LR  - 20230124
IS  - 1600-6135 (Print)
IS  - 1600-6135 (Linking)
VI  - 3
IP  - 1
DP  - 2003 Jan
TI  - Acute humoral rejection in hepatitis C-infected renal transplant recipients 
      receiving antiviral therapy.
PG  - 74-8
AB  - The use of interferon-alpha (IFN) in hepatitis C (HCV)-infected renal recipients 
      has been associated with acute rejection and graft loss. We reviewed our recent 
      experience in HCV (+) renal recipients treated with antiviral therapy for biopsy 
      proven chronic hepatitis C. Twelve HCV (+) recipients who recently received 
      antiviral therapy were analyzed. Post-treatment sera were tested for 
      donor-specific human leukocyte antigen (HLA) antibodies (DSA). Within 6 months of 
      initiating antiviral therapy, two of 12 patients (17%) developed acute rejection, 
      which was characterized as acute humoral rejection (de novo DSA in serum and C4d 
      deposits in peritubular capillaries). Both progressed to graft failure. Nine of 
      the remaining 10 patients tested did not have DSA. The use of IFN was associated 
      with severe acute humoral rejection (C4d +, DSA +). The recognition of 
      IFN-associated acute humoral rejection in this series may explain the high rate 
      of graft loss reported previously in renal recipients receiving IFN.
FAU - Baid, Seema
AU  - Baid S
AD  - Department of Medicine, Massachusetts General Hospital and Harvard Medical 
      School, Boston, MA 02114, USA.
FAU - Tolkoff-Rubin, Nina
AU  - Tolkoff-Rubin N
FAU - Saidman, Susan
AU  - Saidman S
FAU - Chung, Raymond
AU  - Chung R
FAU - Williams, Winfred W
AU  - Williams WW
FAU - Auchincloss, Hugh
AU  - Auchincloss H
FAU - Colvin, Robert B
AU  - Colvin RB
FAU - Delmonico, Francis L
AU  - Delmonico FL
FAU - Cosimi, A Benedict
AU  - Cosimi AB
FAU - Pascual, Manuel
AU  - Pascual M
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Am J Transplant
JT  - American journal of transplantation : official journal of the American Society of 
      Transplantation and the American Society of Transplant Surgeons
JID - 100968638
RN  - 0 (Antiviral Agents)
RN  - 0 (Interferon-alpha)
RN  - 49717AWG6K (Ribavirin)
SB  - IM
MH  - Adult
MH  - Antiviral Agents/*pharmacology
MH  - Female
MH  - Graft Rejection/*immunology
MH  - Hepatitis C/*immunology
MH  - Humans
MH  - Interferon-alpha/pharmacology
MH  - Kidney Transplantation/*immunology
MH  - Male
MH  - Middle Aged
MH  - Ribavirin/pharmacology
EDAT- 2002/12/21 04:00
MHDA- 2003/06/19 05:00
CRDT- 2002/12/21 04:00
PHST- 2002/12/21 04:00 [pubmed]
PHST- 2003/06/19 05:00 [medline]
PHST- 2002/12/21 04:00 [entrez]
AID - S1600-6135(22)07268-9 [pii]
AID - 10.1034/j.1600-6143.2003.30113.x [doi]
PST - ppublish
SO  - Am J Transplant. 2003 Jan;3(1):74-8. doi: 10.1034/j.1600-6143.2003.30113.x.