PMID- 12493015
OWN - NLM
STAT- MEDLINE
DCOM- 20030219
LR  - 20190916
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 190
DP  - 2002 Dec
TI  - Mapping genes for autoimmunity in humans: type 1 diabetes as a model.
PG  - 182-94
AB  - Type 1 diabetes (T1D) arises from autoimmune destruction of the beta cells of the 
      pancreas leading to a complete dependence on exogenous insulin for survival. Like 
      many autoimmune disorders, the etiology of T1D is complex, resulting from the 
      action of multiple genes and environmental factors. Identification of genes that 
      contribute to T1D susceptibility should improve disease prediction and contribute 
      to the understanding of the underlying pathology of the disorder. Two regions of 
      the human genome, the human leukocyte antigen (HLA) region and the insulin gene 
      region are generally thought to contain susceptibility loci for T1D. Although 
      additional putative T1D loci have been reported, the supporting evidence has 
      often been of modest significance and findings have displayed poor 
      reproducibility across multiple studies. This review summarizes the current state 
      of genetic linkage and association studies in T1D and suggests future directions. 
      We argue that much of the difficulty in mapping T1D susceptibility loci has 
      resulted from inadequate sample sizes and we illustrate the substantial gains in 
      power that can be achieved by pooling data across studies. These findings suggest 
      that substantial progress toward the identification of susceptibility genes in 
      T1D and other genetically complex disorders may be achieved through increased 
      collaboration and consortium mapping efforts.
FAU - Onengut-Gumuscu, Suna
AU  - Onengut-Gumuscu S
AD  - Molecular Genetics Program, Virginia Mason Research Center, Seattle, WA 98101, 
      USA.
FAU - Concannon, Patrick
AU  - Concannon P
LA  - eng
GR  - DK46635/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (HLA Antigens)
RN  - 0 (Insulin)
SB  - IM
MH  - Autoimmunity/*genetics
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - Diabetes Mellitus, Type 1/*genetics
MH  - Genetic Linkage
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Insulin/genetics
MH  - Models, Immunological
RF  - 76
EDAT- 2002/12/21 04:00
MHDA- 2003/02/20 04:00
CRDT- 2002/12/21 04:00
PHST- 2002/12/21 04:00 [pubmed]
PHST- 2003/02/20 04:00 [medline]
PHST- 2002/12/21 04:00 [entrez]
AID - imr19014 [pii]
AID - 10.1034/j.1600-065x.2002.19014.x [doi]
PST - ppublish
SO  - Immunol Rev. 2002 Dec;190:182-94. doi: 10.1034/j.1600-065x.2002.19014.x.