PMID- 12493802
OWN - NLM
STAT- MEDLINE
DCOM- 20030723
LR  - 20190513
IS  - 0305-7453 (Print)
IS  - 0305-7453 (Linking)
VI  - 51
IP  - 1
DP  - 2003 Jan
TI  - Comparative spectrum and activity of NVP-PDF386 (VRC4887), a new peptide 
      deformylase inhibitor.
PG  - 157-61
AB  - The antibacterial activity of NVP-PDF386 (VRC4887), a novel peptide deformylase 
      (PDF) inhibitor, was tested against over 1000 recent clinical isolates collected 
      during 2001 and 2002. The MIC(50/90) (mg/L) results for NVP-PDF386 (VRC4887) 
      were: Staphylococcus aureus (SA) 0.5/1, coagulase-negative staphylococci (CoNS) 
      0.5/1, Streptococcus pneumoniae 0.25/0.5, other streptococci 0.25/0.5, 
      enterococci 1/2, Moraxella catarrhalis 0.25/0.25, Haemophilus influenzae 8/32 and 
      Enterobacteriaceae or non-fermentative Gram-negative bacilli >32/>32 mg/L. No 
      differences in NVP-PDF386/(VRC4887) MIC distributions were observed between 
      methicillin-resistant (MR) S. aureus and methicillin-susceptible (MS) S. aureus, 
      MR-CoNS and MS-CoNS, penicillin-susceptible and non-susceptible streptococci, and 
      macrolide-susceptible and -resistant strains. The potency of NVP-PDF386 (VRC4887) 
      compared favourably with those of control compounds, including glycopeptides, 
      oxazolidinones, a streptogramin combination and other agents with activity 
      focused against Gram-positive cocci.
FAU - Jones, Ronald N
AU  - Jones RN
AD  - The JONES Group/JMI Laboratories, 345 Beaver Kreek Centre, Suite A, North 
      Liberty, IA 52317, USA.
FAU - Rhomberg, Paul R
AU  - Rhomberg PR
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Antimicrob Chemother
JT  - The Journal of antimicrobial chemotherapy
JID - 7513617
RN  - 0 (Anti-Infective Agents)
RN  - 0 (Protease Inhibitors)
RN  - EC 3.4.11.- (Aminopeptidases)
RN  - EC 3.5.- (Amidohydrolases)
RN  - EC 3.5.1.88 (peptide deformylase)
SB  - IM
MH  - *Amidohydrolases
MH  - Aminopeptidases/*antagonists & inhibitors
MH  - Anti-Infective Agents/chemistry/*pharmacology
MH  - Humans
MH  - Microbial Sensitivity Tests/statistics & numerical data
MH  - Protease Inhibitors/chemistry/*pharmacology
EDAT- 2002/12/21 04:00
MHDA- 2003/07/24 05:00
CRDT- 2002/12/21 04:00
PHST- 2002/12/21 04:00 [pubmed]
PHST- 2003/07/24 05:00 [medline]
PHST- 2002/12/21 04:00 [entrez]
AID - 10.1093/jac/dkg055 [doi]
PST - ppublish
SO  - J Antimicrob Chemother. 2003 Jan;51(1):157-61. doi: 10.1093/jac/dkg055.