PMID- 12494299
OWN - NLM
STAT- MEDLINE
DCOM- 20030522
LR  - 20220330
IS  - 0954-3007 (Print)
IS  - 0954-3007 (Linking)
VI  - 56
IP  - 12
DP  - 2002 Dec
TI  - Effects of dietary yoghurt on immunological and clinical parameters of 
      rhinopathic patients.
PG  - 1155-61
AB  - OBJECTIVES: To examine the immunological and clinical influence of 4 months' 
      feeding with either yoghurt or partially skimmed milk or nothing, on 20 
      volunteers. SUBJECTS: Thirteen subjects had a demonstrated allergic rhinopathy 
      and seven were healthy subjects and participated as controls. RESEARCH DESIGN: 
      Either a group of seven or a group of six rhinopathic patients were fed either 
      450 g yoghurt or 450 g partially skimmed milk, respectively, for 4 months between 
      March and October 1999. All subjects maintained their usual diet throughout the 
      study. Peripheral blood mononuclear cells (PBMC) were isolated before and after 
      the experimental period and cultured for periods of 40 and 64 h. Proliferation 
      index assay and release of IFNgamma and IL-4 without and with PHA stimulation 
      were assessed. Allergic rhinopathy was evaluated before and after the 4 months 
      period by performing the nasal functionality tests (Active Anterior 
      Rhinomanometry, Acoustic Rhinometry), the prick test, the nasal specific 
      provocation test (NPT), the dosage of specific IgE blood levels, the evaluation 
      of the symptomatological score and the nasal mucociliary transport test. RESULTS: 
      No significant change of the proliferation index was noted among the three 
      groups. Cultured PBMC of the group fed with yoghurt released more IFNgamma and 
      less IL-4. Cytokine plasma levels were at and remained at basal levels. Prick 
      test, specific serum IgEs and NPT remained immodified. Muco-ciliary transport 
      time (MCTt) and symptomatological score showed a definitive improvement after 
      yoghurt feeding. CONCLUSION: Yoghurt feeding appears to improve or prevent 
      allergic recurrences in rhinopatic patients.
FAU - Aldinucci, C
AU  - Aldinucci C
AD  - Institute of General Physiology, University of Siena, Siena, Italy.
FAU - Bellussi, L
AU  - Bellussi L
FAU - Monciatti, G
AU  - Monciatti G
FAU - Passali, G C
AU  - Passali GC
FAU - Salerni, L
AU  - Salerni L
FAU - Passali, D
AU  - Passali D
FAU - Bocci, V
AU  - Bocci V
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Eur J Clin Nutr
JT  - European journal of clinical nutrition
JID - 8804070
RN  - 207137-56-2 (Interleukin-4)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Female
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-4/biosynthesis
MH  - Leukocytes, Mononuclear
MH  - Male
MH  - Manometry
MH  - Milk
MH  - Nasal Provocation Tests
MH  - Probiotics/administration & dosage
MH  - Radioallergosorbent Test
MH  - Rhinitis, Allergic, Perennial/*diet therapy/*immunology
MH  - Secondary Prevention
MH  - Skin Tests
MH  - *Yogurt/microbiology
EDAT- 2002/12/21 04:00
MHDA- 2003/05/23 05:00
CRDT- 2002/12/21 04:00
PHST- 2002/12/21 04:00 [pubmed]
PHST- 2003/05/23 05:00 [medline]
PHST- 2002/12/21 04:00 [entrez]
AID - 10.1038/sj.ejcn.1601465 [doi]
PST - ppublish
SO  - Eur J Clin Nutr. 2002 Dec;56(12):1155-61. doi: 10.1038/sj.ejcn.1601465.