PMID- 12494787
OWN - NLM
STAT- MEDLINE
DCOM- 20030122
LR  - 20171116
IS  - 0001-6659 (Print)
IS  - 0001-6659 (Linking)
VI  - 72
IP  - 3
DP  - 2002
TI  - [Adsorption of neutral polymers on liposomes: investigation of the correlation 
      between liposomes and polymers].
PG  - 166-75
AB  - The characteristics of the adsorption process of neutral polymers: poly(vinyl 
      alcohol), poly(vinyl pyrrolidone), and dextrane onto liposomes with three 
      different lipid compositions were investigated as follows. 1 determination of the 
      amount of polymers adsorbed on the surface of liposomes, 2 detection of the 
      changes in the membrane structure brought by the adsorption of polymers with a 
      high precision densimeter, 3 test dye release experiments with membrane diffusion 
      cells after remote loading of liposomes with acridine orange (AO). The amount of 
      polymers adsorbed on the surface of liposomes was expressed with adsorption 
      isotherms at 25 +/- 1 degrees C. Connections were found between the lipid 
      composition influencing the fluidity of liposome membrane, the surface charge 
      density of liposomes, the physical-chemical properties of the polymers and the 
      quantitative adsorption properties of the polymers. Decreasing of the molar 
      excess volume values counted from the results of the high precision densimetric 
      measurements revealed the compression of the membrane structure caused by polymer 
      adsorption. We were able to influence the test dye (AO) release properties of the 
      soy lecithin phospholipid (SLPL)/cholesterol (Chol)/dicethyl phosphate (DCP) = 
      25:3:2 (mol/mol) liposomes by the changing of the amount of PVA or DEX added to 
      their dispersions.
FAU - Dekany, Gyorgy
AU  - Dekany G
AD  - Szegedi Tudomanyegyetem, Gyogyszertechnologiai Intezet, Szeged, Eotvos u. 
      6.-H-6720.
FAU - Toth, Geza
AU  - Toth G
FAU - Eros, Istvan
AU  - Eros I
LA  - hun
PT  - Journal Article
TT  - Neutralis polimerek adszorpcioja liposzomakon: a liposzomak es polimerek kozotti 
      kolcsonhatas vizsgalata.
PL  - Hungary
TA  - Acta Pharm Hung
JT  - Acta pharmaceutica Hungarica
JID - 0414322
RN  - 0 (Coloring Agents)
RN  - 0 (Dextrans)
RN  - 0 (Liposomes)
RN  - 9002-89-5 (Polyvinyl Alcohol)
RN  - FZ989GH94E (Povidone)
SB  - IM
MH  - Adsorption
MH  - Coloring Agents
MH  - Dextrans/*chemistry
MH  - Liposomes/*chemistry
MH  - Polyvinyl Alcohol/*chemistry
MH  - Povidone/*chemistry
MH  - Structure-Activity Relationship
MH  - Surface Properties
EDAT- 2002/12/24 04:00
MHDA- 2003/01/23 04:00
CRDT- 2002/12/24 04:00
PHST- 2002/12/24 04:00 [pubmed]
PHST- 2003/01/23 04:00 [medline]
PHST- 2002/12/24 04:00 [entrez]
PST - ppublish
SO  - Acta Pharm Hung. 2002;72(3):166-75.